3α-Phenylacetoxy Tropane

Base Information

• Chemical Name: 3α-Phenylacetoxy Tropane
• CAS No.: 1690-22-8
• Molecular Formula: C16H21 N O2
• Molecular Weight: 259.348
• Mol file: 1690-22-8.mol

Synonyms:Aceticacid, phenyl-, 3a-tropanylester (6CI,7CI,8CI); Benzeneacetic acid, 8-methyl-8-azabicyclo[3.2.1]oct-3-ylester, endo-; 3a-Phenylacetoxytropane;NA 181

Chemical Property of 3α-Phenylacetoxy Tropane

Chemical Property:

• Boiling Point: 356.3±35.0 °C(Predicted)
• PKA: 10.03±0.40(Predicted)
• PSA: 29.54000
• Density: 1.13±0.1 g/cm3(Predicted)
• LogP: 2.33540

Purity/Quality:

98% ^*data from raw suppliers

Tropanylphenylacetate ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3α-Phenylacetoxy Tropane is an alkaloid used in the preparation of Atropine.

Technology Process of 3α-Phenylacetoxy Tropane

There total 9 articles about 3α-Phenylacetoxy Tropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

phenylacetic acid (103-82-2) + 3-tropanol (120-29-6) → NA 181 (1690-22-8)

Guidance literature:

With hydrogenchloride; at 145 ℃; for 3h;

DOI:10.1002/jlcr.543

Reference yield: 65.0%

phenylacetyl chloride (103-80-0) + 3-tropanol (120-29-6) → NA 181 (1690-22-8)

Guidance literature:

In chloroform; at 70 - 85 ℃;

Reference yield:

tropine hydrochloride (2292-08-2) + phenylacetyl chloride (103-80-0) → NA 181 (1690-22-8)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 0.0583333h; under 5171.62 Torr; Pressure; Flow reactor;

DOI:10.1016/j.bmc.2017.02.002

upstream raw materials:

(+/-)-acetoxy-phenyl-acetic acid tropane-3endo-yl ester

Ethyl 2-phenylethanoate

3-tropanol

phenylacetyl chloride

Downstream raw materials:

Atropine

apoatropine

atropine

8syn-methyl-8anti-phenacyl-3endo-phenylacetoxy-nortropanium; bromide