3-Iodo-2-Methoxybenzoic acid

Base Information

• Chemical Name: 3-Iodo-2-Methoxybenzoic acid
• CAS No.: 879498-16-5
• Molecular Formula: C8H7IO3
• Molecular Weight: 278.046
• Hs Code.: 2916399090
• Mol file: 879498-16-5.mol

Synonyms:

Chemical Property of 3-Iodo-2-Methoxybenzoic acid

Chemical Property:

• Melting Point: 122 - 124 °C
• Boiling Point: 361.4±32.0 °C(Predicted)
• PKA: 3.74±0.10(Predicted)
• PSA: 46.53000
• Density: 1.878±0.06 g/cm3(Predicted)
• LogP: 1.99800

Purity/Quality:

98% ^*data from raw suppliers

3-Iodo-2-methoxy-benzoicacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Iodo-2-Methoxybenzoic acid

There total 4 articles about 3-Iodo-2-Methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

3-amino-2-methoxybenzoic acid (861306-04-9) → 3-iodo-2-methoxy-benzoic acid (879498-16-5)

Guidance literature:

3-amino-2-methoxybenzoic acid; With hydrogenchloride; sodium nitrite; In ethanol; water; at 0 - 5 ℃;

With sodium iodide; In ethanol; water; at 0 - 20 ℃; for 17h;

Reference yield: 27.0%

2-Methoxybenzoic acid (579-75-9) → 3-iodo-2-methoxy-benzoic acid (879498-16-5)

Guidance literature:

2-Methoxybenzoic acid; With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 2h;

With iodine; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/ol0530427

Reference yield:

3-iodo-2-methoxy-benzaldehyde (874347-49-6) → 3-iodo-2-methoxy-benzoic acid (879498-16-5)

Guidance literature:

With sodium chlorite; 2,3-Dimethyl-2-butene; disodium hydrogen phosphate monohydrate; In water; tert-butyl alcohol; for 0.333333h;

upstream raw materials:

2-Methoxybenzoic acid

3-amino-2-methoxybenzoic acid

3-iodo-2-methoxy-benzaldehyde

2-hydroxy-3-iodo-benzaldehyde

Downstream raw materials:

C₉H₉IO₃

3-iodo-2-methoxy-benzoyl chloride

3-iodo-2-methoxybenzoic acid tert-butyl ester

(3-tert-butoxycarbonyl-2-methoxy-phenyl)methylboronic acid (-)-pinanediolato diester

Refernces

• 1、 -. "Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, composistions thereof and the use for nonsense suppression". Page/Page column 19. . Retrieved 2008/12/06.
• 2、 Nguyen, Thi-Huu,Castanet, Anne-Sophie,Mortier, Jacques. "Directed ortho-metalation of unprotected benzoic acids. Methodology and regioselective synthesis of useful contiguously 3- and 6-substituted 2-methoxybenzoic acid building blocks". . p. 765 - 768. Retrieved 2007/10/03.