Chemical Property of 3-Deoxyglucosone
Chemical Property:
- Vapor Pressure:4.59E-08mmHg at 25°C
- Melting Point:73-75oC
- Refractive Index:1.4230 (estimate)
- Boiling Point:400.1°Cat760mmHg
- PKA:13.17±0.20(Predicted)
- Flash Point:209.9°C
- PSA：94.83000
- Density:1.406g/cm3
- LogP:-2.14140
- Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- Solubility.:Methanol (Slightly), Water (Slightly, Sonicated)
- Water Solubility.:Soluble in water, methanol or hot ethanol.
- XLogP3:-2.4
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:162.05282342
- Heavy Atom Count:11
- Complexity:144
- Purity/Quality:
-
98%, *data from raw suppliers
3-Deoxyglucosone *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C(C(C(CO)O)O)C(=O)C=O
- Isomeric SMILES:C([C@@H]([C@@H](CO)O)O)C(=O)C=O
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Description
3-deoxy Glucosone is a highly reactive 2-oxoaldehyde intermediate of the Maillard reaction produced during oxidative stress in response to excess sugar consumption and in association with diabetes. It is a precursor for the formation of advanced glycation endproducts and because it readily reacts with protein amino groups is also used for crosslinking studies. 3-deoxy Glucosone can be used as a reference for the analysis and detection of glucose degradation products and glycating agents.
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Uses
An intermediate in the Maillard reaction of proteins with glucose, which is metabolised to 3-Deoxyfructose. An intermediate in the formation of pyrraline, which might contribute to a pathological effect, such as carcinogenesis Frequently used as a reference for the analysis and detection of glucose degradation products and glycating agents. Also used for cross-linking studies as it readily reacts with protein amino groups.
