4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE

Base Information

• Chemical Name: 4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE
• CAS No.: 6623-93-4
• Molecular Formula: C16H18 O
• Molecular Weight: 226.318
• Hs Code.: 2909309090
• Mol file: 6623-93-4.mol

Synonyms:Anisole,p-(a,a-dimethylbenzyl)- (7CI,8CI); NSC 55498

Chemical Property of 4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE

Chemical Property:

• Vapor Pressure: 0.000492mmHg at 25°C
• Boiling Point: 323.5°C at 760 mmHg
• Flash Point: 127.3°C
• PSA: 9.23000
• Density: 0.998g/cm³
• LogP: 4.02110

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

1-Methoxy-4-(2-phenylpropan-2-yl)benzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE

There total 12 articles about 4-(1-METHYL-1-PHENYL-ETHYL)-ANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxyphenylboronic acid (5720-07-0) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → 1-(2-(4-methoxyphenyl)propan-2-yl)benzene (6623-93-4)

Guidance literature:

With nickel(II) triflate; methanol; potassium phosphate; 1,3-diaminocyclohexane; In toluene; at 80 ℃; for 24h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202001742

Reference yield: 91.0%

methoxybenzene (100-66-3) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → 1-(2-(4-methoxyphenyl)propan-2-yl)benzene (6623-93-4)

Guidance literature:

With calcium(II) bis(trifluoromethanesulfonyl)imide; tert-butylammonium hexafluorophosphate(V); In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/chem.201001375

Reference yield: 82.0%

methoxybenzene (100-66-3) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → 1-(2-(4-methoxyphenyl)propan-2-yl)benzene (6623-93-4) + 2-(1-methyl-1-phenylethyl)anisole (56751-14-5)

Guidance literature:

methoxybenzene; With o-tetrachloroquinone; [CpMoCl(CO)3]; at 20 ℃; for 0.5h; Inert atmosphere;

isopropenylbenzene; at 150 ℃; for 1h; Inert atmosphere; sealed tube; Microwave irradiation;

DOI:10.1002/chem.200801105

upstream raw materials:

cumenyl chloride

4-methoxyphenyl magnesium bromide

p-cumylphenol

dimethyl sulfate

Downstream raw materials:

p-cumylphenol

[4-(1-methyl-1-phenyl-ethyl)-phenoxy]-acetic acid