5-Fluoro-2,3-dihydrobenzofuran-2-carboxylic acid

Base Information

Chemical Name:5-Fluoro-2,3-dihydrobenzofuran-2-carboxylic acid
CAS No.:89197-63-7
Molecular Formula:C₉H₇FO₃
Molecular Weight:182.151
Hs Code.:
European Community (EC) Number:830-244-0
Mol file:89197-63-7.mol

Synonyms:89197-63-7;5-Fluoro-2,3-dihydrobenzofuran-2-carboxylic acid;5-fluoro-2,3-dihydro-1-benzofuran-2-carboxylic acid;2-Benzofurancarboxylic acid, 5-fluoro-2,3-dihydro-;5-fluoro-2,3-dihydro-benzofuran-2-carboxylic acid;SCHEMBL8888891;QLNKTQSTCJIKOC-UHFFFAOYSA-N;AKOS005218338;CS-0262650;EN300-83337;D86147;5-Fluoro-2,3-dihydrobenzofuran-2-carboxylicacid;F8881-7002;Z359510104

Suppliers and Price of 5-Fluoro-2,3-dihydrobenzofuran-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-fluoro-2,3-dihydro-1-benzofuran-2-carboxylicacid
100mg
$ 265.00

Crysdot
5-Fluoro-2,3-dihydrobenzofuran-2-carboxylicacid 95+%
1g
$ 698.00

Chemenu
5-fluoro-2,3-dihydrobenzofuran-2-carboxylicacid 95%
1g
$ 660.00

Alichem
5-Fluoro-2,3-dihydrobenzofuran-2-carboxylicacid
1g
$ 607.76

AK Scientific
5-Fluoro-2,3-dihydrobenzofuran-2-carboxylicacid
10g
$ 3164.00

Total 6 raw suppliers

Chemical Property of 5-Fluoro-2,3-dihydrobenzofuran-2-carboxylic acid

Chemical Property:

PSA：46.53000
LogP:1.21380
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:182.03792224
Heavy Atom Count:13
Complexity:219

Purity/Quality:

99% ^*data from raw suppliers

5-fluoro-2,3-dihydro-1-benzofuran-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC2=C1C=C(C=C2)F)C(=O)O

Technology Process of 5-Fluoro-2,3-dihydrobenzofuran-2-carboxylic acid

There total 7 articles about 5-Fluoro-2,3-dihydrobenzofuran-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 89197-62-6
5-fluorobenzofuran-2-carboxylic acid

: 89197-63-7
5-fluoro-2,3-dihydro-benzofuran-2-carboxylic acid

Guidance literature:: With sodium amalgam; In sodium hydroxide; for 2.5h;
DOI:10.1021/jm00371a003

Reference yield:

: 135634-27-4
(5-fluoro-2,3-dihydro-benzofuran-2-yl)-methanol

: 89197-63-7
5-fluoro-2,3-dihydro-benzofuran-2-carboxylic acid

Guidance literature:: With sodium hypochlorite solution; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium carbonate; In water; acetonitrile; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 347-54-6
5-fluoro-2-hydroxybenzaldehyde

: 89197-63-7
5-fluoro-2,3-dihydro-benzofuran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / butan-2-one / 4 h / Heating

2: KOH / ethanol / 0.75 h / Heating

3: 62 percent / sodium amalgam / aq. NaOH / 2.5 h

With potassium hydroxide; sodium amalgam; potassium carbonate; In sodium hydroxide; ethanol; butanone;
DOI:10.1021/jm00371a003