2-Thiazoleethanol

Base Information

• Chemical Name: 2-Thiazoleethanol
• CAS No.: 89323-88-6
• Molecular Formula: C5H7NOS
• Molecular Weight: 129.183
• Hs Code.: 2934100090
• European Community (EC) Number: 837-836-8
• DSSTox Substance ID: DTXSID80434420
• Wikidata: Q72508272
• ChEMBL ID: CHEMBL4542341
• Mol file: 89323-88-6.mol

Synonyms:2-THIAZOLEETHANOL;89323-88-6;2-(Thiazol-2-yl)ethanol;2-(1,3-thiazol-2-yl)ethanol;2-(1,3-thiazol-2-yl)ethan-1-ol;hydroxyethylthiazole;SCHEMBL841789;2-(thiazol-2-yl)ethan-1-ol;CHEMBL4542341;DTXSID80434420;MFCD13184161;AKOS016011949;AB93261;FT-0718755;EN300-138099;F8888-7822

Chemical Property of 2-Thiazoleethanol

Chemical Property:

• Boiling Point: 236oC
• Flash Point: 97oC
• PSA: 61.36000
• Density: 1.26
• LogP: 0.67790
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 129.02483502
• Heavy Atom Count: 8
• Complexity: 69.4

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-(1,3-thiazol-2-yl)ethan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=N1)CCO

Technology Process of 2-Thiazoleethanol

There total 5 articles about 2-Thiazoleethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-methylthiazole (3581-87-1,260998-77-4) → 2-(2-Hydroxyethyl)thiazole (89323-88-6)

Guidance literature:

at 140 ℃; for 3h; Sealed tube;

Reference yield: 15.5%

1,3-thiazole (288-47-1) → 2-(2-Hydroxyethyl)thiazole (89323-88-6)

Guidance literature:

In diethyl ether;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-methylthiazole (3581-87-1,260998-77-4) → 5-(hydroxymethyl)-2-methylthiazole (56012-38-5) + 2-(2-Hydroxyethyl)thiazole (89323-88-6)

Guidance literature:

Multistep reaction; (i) nBuLi, Et₂O, (ii) /BRN= 1209228/;

upstream raw materials:

oxirane

1,3-thiazole

formaldehyd

2-methylthiazole

Downstream raw materials:

2-(1,3-thiazol-2-yl)ethyl 4-methylbenzenesulfonate