4,5-Dihydro-1,3,2-dioxaphosphole 2-oxide

Base Information

• Chemical Name: 4,5-Dihydro-1,3,2-dioxaphosphole 2-oxide
• CAS No.: 1003-11-8
• Molecular Formula: C2H5 O3 P
• Molecular Weight: 108.034
• Hs Code.: 2931900090
• DSSTox Substance ID: DTXSID10905330
• Wikidata: Q82873794
• Mol file: 1003-11-8.mol

Synonyms:Ethylenephosphonate ((C2H4O2)HPO) (6CI,7CI); Phosphonic acid, cyclic ethylene ester(8CI); Ethylene glycol, cyclic phosphonate (8CI); 2-Oxo-1,3,2-dioxaphospholane;2H-1,3,2-Dioxaphospholan-2-one; Ethylene cyclic phosphite; Ethylene glycolcyclic phosphite; Ethylenephosphite ((C2H4O2)(HO)P)

Chemical Property of 4,5-Dihydro-1,3,2-dioxaphosphole 2-oxide

Chemical Property:

• Boiling Point: 151.6±7.0 °C(Predicted)
• PSA: 69.67000
• LogP: 0.69060
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 106.98980598
• Heavy Atom Count: 6
• Complexity: 63.2

Purity/Quality:

98%,99%, ^*data from raw suppliers

ETHYLENE PHOSPHITE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CO[P+](=O)O1

Technology Process of 4,5-Dihydro-1,3,2-dioxaphosphole 2-oxide

There total 10 articles about 4,5-Dihydro-1,3,2-dioxaphosphole 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Eth-(E)-ylidene-(2-oxo-2λ5-[1,3,2]dioxaphospholan-2-yl)-amine → 2-oxo-1,3,2-dioxaphospholane (1003-11-8) + acetonitrile (75-05-8,26809-02-9)

Guidance literature:

Heating;

Reference yield:

2-chloro-1,3,2-dioxaphospholan (822-39-9) + Benzaldoxime (932-90-1) → 2-oxo-1,3,2-dioxaphospholane (1003-11-8) + Benzaldehyde O-[1,3,2]dioxaphospholan-2-yl-oxime + (2-Oxo-2λ5-[1,3,2]dioxaphospholan-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine + C9H9NO3P + benzonitrile (100-47-0)

Guidance literature:

Mechanism; Product distribution;

Reference yield:

ethylene glycol (107-21-1) → 2-oxo-1,3,2-dioxaphospholane (1003-11-8)

Guidance literature:

With 1,4-dioxane; phosphorus trichloride; Behandlung des Reaktionsgemisches mit NH₃;

DOI:10.1021/ja01168a032

upstream raw materials:

ethylene glycol

bis(O,O'-ethylene) diphosphite

diethylamine

2-acetoxy-[1,3,2]dioxaphospholane

Downstream raw materials:

ethylene (α-anilinobenzyl)phosphonate

bis(2-hydroxyethyl) 2-((3-(benzyloxy)-9,9-dimethyl-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carboxamido)methyl)-5-fluorophenylphosphonate

C₂₆H₂₇FN₃O₇P

2-hydroxyethyl hydrogen 2-((3-(benzyloxy)-9,9-dimethyl-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carboxamido)methyl)-5-fluorophenylphosphonate

Refernces

• 1、 Tzokov, Svetomir B.,Vassilev, Nikolay G.,Momtcheva, Rositza T.,Kaneti, Jose,Petkov, Dimiter D.. "H-tetraoxaspirophosphoranes as possible intermediates in the phosphonylation by phosphorous acid / oxiranes". . p. 187 - 196. Retrieved 2007/10/03.
• 2、 Osipova, M. P.,Volkova, R. V.,Zlobina, I. A.. "REACTION OF N,N-DIALKYL GLYCOL PHOSPHOROUS ACID AMIDES WITH OXIMES". . p. 621. Retrieved 2007/10/02.