2-Hydroxyethyl phosphate

Base Information

• Chemical Name: 2-Hydroxyethyl phosphate
• CAS No.: 1892-26-8
• Molecular Formula: C2H7 O5 P
• Molecular Weight: 142.048
• Hs Code.: 2919900090
• European Community (EC) Number: 217-575-0
• UNII: V9Q6CQQ956
• DSSTox Substance ID: DTXSID6062046
• Nikkaji Number: J199.717C
• Wikidata: Q27191224
• Metabolomics Workbench ID: 123497
• ChEMBL ID: CHEMBL144651
• Mol file: 1892-26-8.mol

Synonyms:2-Hydroxyethyl phosphate;1892-26-8;2-hydroxyethyl dihydrogen phosphate;1,2-Ethanediol, 1-(dihydrogen phosphate);1,2-Ethanediol, mono(dihydrogen phosphate);hydroxyethyl phosphate;ethylene glycol monophosphate;Phosphoric acid, beta-hydroxyethyl ester;Ethylene glycol, monophosphated;V9Q6CQQ956;(2-hydroxyethoxy)phosphonic acid;EINECS 217-575-0;ethylene glycol phosphate;UNII-V9Q6CQQ956;SCHEMBL26209;C2H7O5P;CHEMBL144651;DTXSID6062046;CHEBI:111507;C2-H7-O5-P;.BETA.-HYDROXYETHYL PHOSPHATE;AKOS030254797;ETHANE-1,2-DIOL 1-PHOSPHATE;1,2-Ethanediol 1-dihydrogen phosphate;phosphoric acid mono(2-hydroxyethyl) ester;EN300-7602662;Q27191224

Chemical Property of 2-Hydroxyethyl phosphate

Chemical Property:

• Vapor Pressure: 3.67E-07mmHg at 25°C
• Boiling Point: 375.1°Cat760mmHg
• PKA: 1.82±0.10(Predicted)
• Flash Point: 180.7°C
• PSA: 96.80000
• Density: 1.679g/cm³
• LogP: -0.91200
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)
• XLogP3: -2.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 142.00311032
• Heavy Atom Count: 8
• Complexity: 94.6

Purity/Quality:

99% ^*data from raw suppliers

2-HydroxyethylPhosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COP(=O)(O)O)O
• Uses: 2-Hydroxyethyl Phosphate is a required intermediate in Fosfomycin (F727502) biosynthesis.

Technology Process of 2-Hydroxyethyl phosphate

There total 19 articles about 2-Hydroxyethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-1,3,2-dioxaphospholane-2-oxide (2196-04-5) → phosphoric acid mono-(2-hydroxy-ethyl) ester (1892-26-8) + methyl 2-hydroxyethyl phosphate (67846-69-9) + 2-oxo-2λ5-[1,3,2]dioxaphospholan-2-ol (6711-47-3)

Guidance literature:

With sodium hydroxide; Rate constant; Kinetics; Mechanism; Ambient temperature; determination of 18O-labeled intermediates; pH-product profiles (ratios analyzed by 31P-NMR);

DOI:10.1021/jo00197a041

Reference yield:

ethylene glycol (107-21-1) → phosphoric acid mono-(2-hydroxy-ethyl) ester (1892-26-8)

Guidance literature:

With PPA; at 100 ℃; for 18h;

DOI:10.1002/hlca.19600430161

Reference yield:

ethylene glycol (107-21-1) → phosphoric acid mono-(2-hydroxy-ethyl) ester (1892-26-8) + 2-oxo-2λ5-[1,3,2]dioxaphospholan-2-ol (6711-47-3) + phosphoric acid bis-(2-hydroxy-ethyl) ester (18924-97-5)

Guidance literature:

With pyrophosphoric acid; at 100 ℃; for 1h; Yield given;

DOI:10.1246/bcsj.54.1891

upstream raw materials:

oxirane

2-oxo-1,3,2-dioxaphospholane

Tris(2-chloroethyl) phosphate

2-chloro-ethanol

Downstream raw materials:

methyl 2-hydroxyethyl phosphate