2-(4-Methylphenyl)naphtho[2,1-D][1,3]thiazole

Base Information

• Chemical Name: 2-(4-Methylphenyl)naphtho[2,1-D][1,3]thiazole
• CAS No.: 90016-95-8
• Molecular Formula: C18H13NS
• Molecular Weight: 275.374
• DSSTox Substance ID: DTXSID20520831
• Wikidata: Q82384962
• Mol file: 90016-95-8.mol

Synonyms:90016-95-8;2-(4-METHYLPHENYL)NAPHTHO[2,1-D][1,3]THIAZOLE;DTXSID20520831

Chemical Property of 2-(4-Methylphenyl)naphtho[2,1-D][1,3]thiazole

Chemical Property:

• XLogP3: 5.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 275.07687059
• Heavy Atom Count: 20
• Complexity: 336

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=NC3=C(S2)C4=CC=CC=C4C=C3

Technology Process of 2-(4-Methylphenyl)naphtho[2,1-D][1,3]thiazole

There total 8 articles about 2-(4-Methylphenyl)naphtho[2,1-D][1,3]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methyl-benzaldehyde (104-87-0) + naphthalen-2-ylamine (91-59-8) → 2-(p-tolyl)naphtho[2,1-d]thiazole (90016-95-8)

Guidance literature:

With sulfur; ammonium iodide; In dimethyl sulfoxide; chlorobenzene; at 140 ℃; for 24h; Molecular sieve;

DOI:10.1021/acs.orglett.7b02168

Reference yield: 95.0%

N-(4-methylbenzyl)naphthalen-2-amine → 2-(p-tolyl)naphtho[2,1-d]thiazole (90016-95-8)

Guidance literature:

With sulfur; dimethyl sulfoxide; at 140 ℃; for 22h; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1039/c7cc07366f

Reference yield: 86.0%

naphthalen-2-ylamine (91-59-8) + para-methylbenzylamine (104-84-7) → 2-(p-tolyl)naphtho[2,1-d]thiazole (90016-95-8)

Guidance literature:

With oxygen; sulfur; potassium iodide; In acetonitrile; at 20 - 120 ℃; for 12h; Sealed tube; Green chemistry;

DOI:10.1016/j.tet.2021.132624

upstream raw materials:

2-Amino-1-iodonaphthalene

Copper(I); 4-methyl-benzenecarbothioate

4-methyl-benzaldehyde

naphthalen-2-ylamine