2-(4-{2-[8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]ethyl}-1-piperazinyl)ethyl 2-chlorobenzoate

Base Information

Chemical Name:2-(4-{2-[8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]ethyl}-1-piperazinyl)ethyl 2-chlorobenzoate
CAS No.:90069-23-1
Molecular Formula:C31H34ClF2N3O2
Molecular Weight:554.07000
Hs Code.:
Mol file:90069-23-1.mol

Synonyms:

Suppliers and Price of 2-(4-{2-[8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]ethyl}-1-piperazinyl)ethyl 2-chlorobenzoate

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Chemical Property of 2-(4-{2-[8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]ethyl}-1-piperazinyl)ethyl 2-chlorobenzoate

Chemical Property:

PSA：36.02000
LogP:5.76570

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 2-(4-{2-[8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]ethyl}-1-piperazinyl)ethyl 2-chlorobenzoate

There total 5 articles about 2-(4-{2-[8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]ethyl}-1-piperazinyl)ethyl 2-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 609-65-4
o-chlorobenzoyl chloride

: 90069-21-9
2-(4-{2-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethanol

: 90069-23-1
2-Chloro-benzoic acid 2-(4-{2-[8-fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethyl ester

Guidance literature:: With potassium carbonate; In chloroform; for 1h; Heating;
DOI:10.1135/cccc19810148

Reference yield:

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 90069-23-1
2-Chloro-benzoic acid 2-(4-{2-[8-fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / benzene / 9 h / Heating

2: 100 percent / LiAlH₄ / diethyl ether; benzene / 7 h / Heating

3: 90 percent / K₂CO₃ / CHCl₃ / 1 h / Heating

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; chloroform; benzene;
DOI:10.1135/cccc19810148

Reference yield:

: 68351-39-3
8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

: 90069-23-1
2-Chloro-benzoic acid 2-(4-{2-[8-fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / K₂CO₃ / CHCl₃ / 1 h / Heating

2: 93 percent / benzene / 9 h / Heating

3: 100 percent / LiAlH₄ / diethyl ether; benzene / 7 h / Heating

4: 90 percent / K₂CO₃ / CHCl₃ / 1 h / Heating

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; chloroform; benzene;
DOI:10.1135/cccc19810148