2-(4-{2-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethanol

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Chemical Name:2-(4-{2-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethanol
CAS No.:90069-21-9
Molecular Formula:C₂₄H₃₁F₂N₃O
Molecular Weight:415.526
Hs Code.:

Synonyms:2-(4-{2-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethanol

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Chemical Property of 2-(4-{2-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethanol

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Technology Process of 2-(4-{2-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethanol

There total 4 articles about 2-(4-{2-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 77796-03-3
1-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-2-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-ethanone

: 90069-21-9
2-(4-{2-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; benzene; for 7h; Heating;
DOI:10.1135/cccc19810148

Reference yield:

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 90069-21-9
2-(4-{2-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / benzene / 9 h / Heating

2: 100 percent / LiAlH₄ / diethyl ether; benzene / 7 h / Heating

With lithium aluminium tetrahydride; In diethyl ether; benzene;
DOI:10.1135/cccc19810148

Reference yield:

: 68351-39-3
8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

: 90069-21-9
2-(4-{2-[8-Fluoro-5-(4-fluoro-phenyl)-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-ethyl}-piperazin-1-yl)-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / K₂CO₃ / CHCl₃ / 1 h / Heating

2: 93 percent / benzene / 9 h / Heating

3: 100 percent / LiAlH₄ / diethyl ether; benzene / 7 h / Heating

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; chloroform; benzene;
DOI:10.1135/cccc19810148