sodium 4-(4-{[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl]sulfanyl}phenyl)-4-hydroxy-3-methylbutanoate

Base Information

• Chemical Name: sodium 4-(4-{[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl]sulfanyl}phenyl)-4-hydroxy-3-methylbutanoate
• CAS No.: 91541-81-0
• Molecular Formula: C₂₅H₃₁O₆S*Na
• Molecular Weight: 482.573
• Mol file: 91541-81-0.mol

Synonyms:

Chemical Property of sodium 4-(4-{[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl]sulfanyl}phenyl)-4-hydroxy-3-methylbutanoate

Chemical Property:

• Vapor Pressure: 1.47E-19mmHg at 25°C
• Boiling Point: 682.4°Cat760mmHg
• Flash Point: 366.5°C
• Density: g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of sodium 4-(4-{[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl]sulfanyl}phenyl)-4-hydroxy-3-methylbutanoate

There total 12 articles about sodium 4-(4-{[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl]sulfanyl}phenyl)-4-hydroxy-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-<(3-bromopropyl)oxy>-2-hydroxy-3-propylacetophenone (40786-20-7) → Sodium; 4-{4-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-hydroxy-3-methyl-butyrate (91541-76-3,91541-81-0,91541-85-4,91584-72-4,100443-69-4,103365-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / butan-2-one / 4 h / Heating

2: NaOH / methanol; tetrahydrofuran

With sodium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; butanone;

DOI:10.1021/jm00159a003

Reference yield:

3-(4-hydroxybenzoyl)propionic acid (56872-39-0) → Sodium; 4-{4-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-hydroxy-3-methyl-butyrate (91541-76-3,91541-81-0,91541-85-4,91584-72-4,100443-69-4,103365-84-0)

Guidance literature:

Multi-step reaction with 9 steps

1: NaH / dimethylformamide

2: 1.) KH / 1.) THF

3: NaOH / methanol

4: NaBH₄

5: TFA / CH₂Cl₂

6: NaOMe / methanol

7: K₂CO₃ / butan-2-one / 4 h / Heating

8: NaOH / methanol; tetrahydrofuran

With sodium hydroxide; sodium tetrahydroborate; sodium methylate; potassium hydride; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; butanone;

DOI:10.1021/jm00159a003

Reference yield:

methoxybenzene (100-66-3) → Sodium; 4-{4-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-hydroxy-3-methyl-butyrate (91541-76-3,91541-81-0,91541-85-4,91584-72-4,100443-69-4,103365-84-0)

Guidance literature:

Multi-step reaction with 11 steps

1: AlCl₃ / 1,2-dichloro-ethane / 0 °C

2: HBr, HOAc / Heating

3: NaH / dimethylformamide

4: 1.) KH / 1.) THF

5: NaOH / methanol

6: NaBH₄

7: TFA / CH₂Cl₂

8: NaOMe / methanol

9: K₂CO₃ / butan-2-one / 4 h / Heating

10: NaOH / methanol; tetrahydrofuran

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; hydrogen bromide; sodium methylate; potassium hydride; sodium hydride; potassium carbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; butanone;

DOI:10.1021/jm00159a003

upstream raw materials:

sodium (βR*,γS*)-4-<<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl>thio>-γ-hydroxy-β-methylbenzenebutanoate

4-<(3-bromopropyl)oxy>-2-hydroxy-3-propylacetophenone

3-(4-hydroxybenzoyl)propionic acid

methoxybenzene