Methyl 2-(4-oxoquinazolin-3-yl)acetate

Base Information

Chemical Name:Methyl 2-(4-oxoquinazolin-3-yl)acetate
CAS No.:54368-19-3
Molecular Formula:C₁₁H₁₀N₂O₃
Molecular Weight:218.212
Hs Code.:2933990090
European Community (EC) Number:809-281-1
DSSTox Substance ID:DTXSID60352572
Wikidata:Q82129794
ChEMBL ID:CHEMBL1608003
Mol file:54368-19-3.mol

Synonyms:54368-19-3;methyl 2-(4-oxoquinazolin-3-yl)acetate;(4-Oxo-4H-quinazolin-3-yl)-acetic acid methyl ester;methyl 2-(4-oxo-3,4-dihydroquinazolin-3-yl)acetate;Methyl 2-(4-oxoquinazolin-3(4H)-yl)acetate;methyl (4-oxoquinazolin-3(4H)-yl)acetate;MLS000534197;CBMicro_031822;CHEMBL1608003;SCHEMBL17164022;DTXSID60352572;QKUMWDDGSYLSBF-UHFFFAOYSA-N;HMS1722H15;HMS2293L22;MFCD02078927;STL257385;AKOS000416712;SMR000141634;BIM-0031951.P001;methyl (4-oxo-3(4H)-quinazolinyl)acetate;CS-0219855;Methyl2-(4-oxoquinazolin-3(4H)-yl)acetate;EN300-05127;SR-01000459557;SR-01000459557-1;Z24108410;(4-Oxo-4H-quinazolin-3-yl)-acetic acid, methyl ester

Suppliers and Price of Methyl 2-(4-oxoquinazolin-3-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID METHYL ESTER 95.00%
5G
$ 1548.26

American Custom Chemicals Corporation
(4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID METHYL ESTER 95.00%
2.5G
$ 1227.82

American Custom Chemicals Corporation
(4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID METHYL ESTER 95.00%
1G
$ 852.55

Total 5 raw suppliers

Chemical Property of Methyl 2-(4-oxoquinazolin-3-yl)acetate

Chemical Property:

Vapor Pressure:8.75E-06mmHg at 25°C
Boiling Point:373.8°C at 760 mmHg
Flash Point:179.9°C
PSA：61.19000
Density:1.29g/cm³
LogP:0.56950
XLogP3:0.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:218.06914219
Heavy Atom Count:16
Complexity:327

Purity/Quality:

99% ^*data from raw suppliers

(4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)CN1C=NC2=CC=CC=C2C1=O

Technology Process of Methyl 2-(4-oxoquinazolin-3-yl)acetate

There total 11 articles about Methyl 2-(4-oxoquinazolin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 491-36-1
4-Hydroxyquinazoline

: 96-32-2
bromoacetic acid methyl ester

: 54368-19-3
3-methoxycarbonylmethyl-3,4-dihydro-4(1H)-quinazoline

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 4h; regioselective reaction;
DOI:10.1021/acs.jmedchem.6b00039

Reference yield: 77.0%

: 82185-40-8
2-amine-N-(methoxycarbonylmethyl)benzamide

: 149-73-5
trimethyl orthoformate

: 54368-19-3
3-methoxycarbonylmethyl-3,4-dihydro-4(1H)-quinazoline

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 40 ℃; for 2h;
DOI:10.3987/COM-04-10130

Reference yield: 49.0%

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 491-36-1,134434-33-6
4-quinazolinol

: 54368-19-3
3-methoxycarbonylmethyl-3,4-dihydro-4(1H)-quinazoline

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetlet.2010.01.087