4-(2-(4-(((3,5-dichloroanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid)

Base Information

• Chemical Name: 4-(2-(4-(((3,5-dichloroanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid)
• CAS No.: 131179-94-7
• Molecular Formula: C₁₈H₁₇Cl₂NO₄
• Molecular Weight: 382.243
• Mol file: 131179-94-7.mol

Synonyms:RSR 4

Chemical Property of 4-(2-(4-(((3,5-dichloroanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid)

Chemical Property:

• Vapor Pressure: 8.75E-15mmHg at 25°C
• Boiling Point: 590.4°Cat760mmHg
• Flash Point: 310.9°C
• PSA: 79.12000
• Density: 1.388g/cm³
• LogP: 5.06610

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-(4-(((3,5-dichloroanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid)

There total 3 articles about 4-(2-(4-(((3,5-dichloroanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

chloroform (67-66-3,8013-54-5) + 4-<<(3,5-dichloroanilino)carbonyl>methyl>phenol (131179-76-5) + acetone (67-64-1) → 2-[4-((((3,5-dichlorophenyl)amino)-carbonyl)methyl)phenoxy]-2-methyl propionic acid (131179-94-7)

Guidance literature:

With sodium hydroxide; for 12h; Ambient temperature;

DOI:10.1021/jm00106a041

Reference yield:

4-hydroxyphenylacetate (156-38-7) → 2-[4-((((3,5-dichlorophenyl)amino)-carbonyl)methyl)phenoxy]-2-methyl propionic acid (131179-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) thionyl chloride / 1.) reflux, 30 min, 2.) xylene, reflux, 3 h

2: 42 percent / NaOH / 12 h / Ambient temperature

With sodium hydroxide; thionyl chloride;

DOI:10.1021/jm00106a041

Reference yield:

3,5-Dichloroaniline (626-43-7) → 2-[4-((((3,5-dichlorophenyl)amino)-carbonyl)methyl)phenoxy]-2-methyl propionic acid (131179-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) thionyl chloride / 1.) reflux, 30 min, 2.) xylene, reflux, 3 h

2: 42 percent / NaOH / 12 h / Ambient temperature

With sodium hydroxide; thionyl chloride;

DOI:10.1021/jm00106a041

upstream raw materials:

chloroform

4-<<(3,5-dichloroanilino)carbonyl>methyl>phenol

acetone

4-hydroxyphenylacetate