1,5-Dimethyl-3,3-diphenyl-2-pyrrolidone

Base Information

• Chemical Name: 1,5-Dimethyl-3,3-diphenyl-2-pyrrolidone
• CAS No.: 30223-75-7
• Molecular Formula: C18H19 N O
• Molecular Weight: 265.355
• Hs Code.: 2933790090
• Mol file: 30223-75-7.mol

Synonyms:1,5-Dimethyl-3,3-diphenyl-2-pyrrolidone

Chemical Property of 1,5-Dimethyl-3,3-diphenyl-2-pyrrolidone

Chemical Property:

• Vapor Pressure: 3.71E-07mmHg at 25°C
• Boiling Point: 416.8°Cat760mmHg
• Flash Point: 169.8°C
• PSA: 20.31000
• Density: 1.091g/cm³
• LogP: 3.16120

Purity/Quality:

99%min ^*data from raw suppliers

1,5-DIMETHYL-3,3-DIPHENYL-2-PYRROLIDONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of phenytoin-like anticonvulsant drugs.

Technology Process of 1,5-Dimethyl-3,3-diphenyl-2-pyrrolidone

There total 17 articles about 1,5-Dimethyl-3,3-diphenyl-2-pyrrolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(+/-)-2-imino-1,5-dimethyl-3,3-diphenylpyrrolidine hydrochloride (17268-74-5,87274-97-3) → (+/-)-1,5-dimethyl-3,3-diphenyl-2-pyrrolidone (30223-75-7)

Guidance literature:

With cis-nitrous acid;

DOI:10.1002/jps.2600720627

Reference yield: 44.0%

Methyltriphenylphosphonium bromide (1779-49-3) + 5-Hydroxy-1-methyl-3,3-diphenyl-pyrrolidin-2-one (77199-54-3) → (+/-)-1,5-dimethyl-3,3-diphenyl-2-pyrrolidone (30223-75-7)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 80 ℃; for 26h;

Reference yield:

(R,S)-2,2-diphenyl-4-dimethylaminopentanenitrile (125-79-1) → (+/-)-1,5-dimethyl-3,3-diphenyl-2-pyrrolidone (30223-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous sulfuric acid

2: thionyl chloride; chloroform

With thionyl chloride; chloroform; sulfuric acid;

DOI:10.1039/jr9490000648

upstream raw materials:

(+/-)-4-Dimethylamino-2,2-diphenylpentanoic acid

5-methyl-3,3-diphenyl-pyrrolidin-2-one

methyl iodide

Methyltriphenylphosphonium bromide

Refernces

• 1、 Brine,Boldt. "Synthesis and anticonvulsant screening of 3,3-diphenyl-2-pyrrolidone derivatives". . p. 700 - 702. Retrieved 2007/10/02.