1-(Hydroxymethyl)-o-carborane

Base Information

• Chemical Name: 1-(Hydroxymethyl)-o-carborane
• CAS No.: 19610-34-5
• Molecular Formula: C3H14 B10 O
• Molecular Weight: 174.254
• Mol file: 19610-34-5.mol

Synonyms:(1,2-Dicarbadodecaboran(12)-1-yl)methanol;(Hydroxymethyl)dekene; 1-(Hydroxymethyl)-1,2-dicarbadodecaborane(12);1-(Hydroxymethyl)-o-carborane; Dekenylmethanol

Chemical Property of 1-(Hydroxymethyl)-o-carborane

Chemical Property:

• PSA: 20.23000
• LogP: -4.15990

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Hydroxymethyl)-o-carborane

There total 15 articles about 1-(Hydroxymethyl)-o-carborane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(C2B10H10(Si(CH3)2C(CH3)3))2(CH2)4 (135457-09-9) → (1'-hydroxymethyl)-1,2-dicarba-closo-dodecaborane (19610-34-5)

Guidance literature:

With LiAlH₄; In tetrahydrofuran; reaction at -78 to 0°C, 20 minutes;;

Reference yield: 86.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,2-dicarba-closo-dodecaborane(12) (16872-09-6) → (1'-hydroxymethyl)-1,2-dicarba-closo-dodecaborane (19610-34-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; room temp., 10 min;

DOI:10.1021/ja973832e

Reference yield: 86.0%

propargyl alcohol (107-19-7) → (1'-hydroxymethyl)-1,2-dicarba-closo-dodecaborane (19610-34-5)

Guidance literature:

With C₂₁H₃₆AgNOP⁽¹⁺⁾*NO₃^(1-); In toluene; at 40 ℃; for 2h; Reagent/catalyst; Temperature; Time; Inert atmosphere;

DOI:10.1002/anie.201311012

upstream raw materials:

formaldehyd

1,2-dicarba-closo-dodecaborane⁽¹²⁾

nido-decaborane

Propargyl acetate

Downstream raw materials:

4-formylbenzoyloxymethylene-o-C-carborane

closo-[1-SPh-2-CH₂OH-1,2-C₂B₁₀H₁₀]

1-(CH₂Cl)-1,2-C₂HB₁₀H₁₀

tris(o-carboranylmethyl) phosphate

Refernces

• 1、 Feinhals, Alexander,Friedrichs, Jan-Simon Jeshua,Hey-Hawkins, Evamarie,Kellert, Martin,L?nnecke, Peter,Tepper, Jonas,Ullrich, Nadine Anke. "Modular synthetic approach to carboranyl-biomolecules conjugates". . . Retrieved 2021.
• 2、 -. "Carborane containing phenylalanine compound, preparation method therefor and use of carborane containing phenylalanine compound". Paragraph 0070; 0084-0087. . Retrieved 2019/08/12.