1-[4-[4-(1-Hydroxyethyl)phenoxy]phenyl]ethanol

Base Information

• Chemical Name: 1-[4-[4-(1-Hydroxyethyl)phenoxy]phenyl]ethanol
• CAS No.: 5325-82-6
• Molecular Formula: C16H18O3
• Molecular Weight: 258.317
• NSC Number: 219
• DSSTox Substance ID: DTXSID70276972
• Mol file: 5325-82-6.mol

Synonyms:1-[4-[4-(1-hydroxyethyl)phenoxy]phenyl]ethanol;5325-82-6;NSC219;ChemDiv3_000331;Oprea1_628975;Oprea1_682525;SCHEMBL4941225;DTXSID70276972;NSC 219;NSC-219;HMS1473P01;ZINC00262378;bis[4-(1-hydroxyethyl)phenyl] ether;CCG-103418;IDI1_019649;NCGC00175983-01;1,1'-[oxybis(4,1-phenylene)]diethanol;EU-0033600;SR-01000392047;4,4'-OXYBIS-[.ALPHA.-METHYLBENZYL ALCOHOL];SR-01000392047-1

Chemical Property of 1-[4-[4-(1-Hydroxyethyl)phenoxy]phenyl]ethanol

Chemical Property:

• Boiling Point: 409.2°Cat760mmHg
• Flash Point: 201.3°C
• Density: 1.162g/cm³
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 258.125594432
• Heavy Atom Count: 19
• Complexity: 227

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=C(C=C1)OC2=CC=C(C=C2)C(C)O)O

Technology Process of 1-[4-[4-(1-Hydroxyethyl)phenoxy]phenyl]ethanol

There total 3 articles about 1-[4-[4-(1-Hydroxyethyl)phenoxy]phenyl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4,4'-oxydiacetophenone (2615-11-4) → bis<4-(1-hydroxyethyl)phenyl> ether (5325-82-6)

Guidance literature:

With hydrogen; nickel; In ethanol; at 20 ℃; under 15200 - 76000 Torr;

DOI:10.1023/A:1025759808918

Reference yield:

diphenylether (101-84-8) → bis<4-(1-hydroxyethyl)phenyl> ether (5325-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / AlCl₃ / CH₂Cl₂ / 20 °C

2: 85 percent / Raney nickel; H₂ / ethanol / 20 °C / 15200 - 76000 Torr

With aluminium trichloride; hydrogen; nickel; In ethanol; dichloromethane; 1: Friedel-Crafts acylation;

DOI:10.1023/A:1025759808918

Reference yield:

→ bis<4-(1-hydroxyethyl)phenyl> ether (5325-82-6)

Guidance literature:

Bis-(4-acetyl)phenylether (IV), Red. m. H2/Raney-Ni;

upstream raw materials:

4,4'-oxydiacetophenone

diphenylether

Downstream raw materials:

bis<4-(1-ethoxyethyl)phenyl> ether

bis<4-(1-hydroxyethyl)phenyl> ether diacetate

bis<4-(1-isopropoxyethyl)phenyl> ether

4,4'-divinyldiphenyl ether