4-Acetylphenyl ether

Base Information

• Chemical Name: 4-Acetylphenyl ether
• CAS No.: 2615-11-4
• Molecular Formula: C16H14O3
• Molecular Weight: 254.285
• Hs Code.: 2914509090
• European Community (EC) Number: 673-038-4
• NSC Number: 214
• UNII: E8X8CW85T5
• DSSTox Substance ID: DTXSID40180774
• Nikkaji Number: J83.928K
• Wikidata: Q83051381
• ChEMBL ID: CHEMBL1531481
• Mol file: 2615-11-4.mol

Synonyms:4-Acetylphenyl ether;2615-11-4;1-[4-(4-Acetylphenoxy)phenyl]ethanone;4-Acetylphenylether;4,4'-Diacetyldiphenyl ether;1,1'-(oxybis(4,1-phenylene))diethanone;Bis(p-acetylphenyl)ether;Bis(4-acetylphenyl)ether;p,p'-Diacetyldiphenyl ether;ACETOPHENONE, 4',4'''-OXYDI-;4,4'-Oxydiacetophenone;Bis(4-acetylphenyl) ether;1,1'-(Oxydi-4,1-phenylene)bisethanone;4,4'-Diacetyldiphenyl oxide;1,1'-(oxydibenzene-4,1-diyl)diethanone;4,4'-Oxybis(acetetophenone);E8X8CW85T5;Ethanone, 1,1'-(oxydi-4,1-phenylene)bis-;NSC 214;NSC-214;BRN 1117740;1-[4-(4-acetylphenoxy)phenyl]ethan-1-one;Ethanone,1,1'-(oxydi-4,1-phenylene)bis-;1,1'-(oxybis(4,1-phenylene))bis(ethan-1-one);CBMicro_011466;EC-000.1431;Cambridge id 5156623;UNII-E8X8CW85T5;MLS000573755;SCHEMBL203697;F0020-1773;NSC214;CHEMBL1531481;DTXSID40180774;HMS2355P10;SMSF0003960;4',4'''-OXYDIACETOPHENONE;4,4'-DIACETYL-DIPHENYLETHER;BBL008202;MFCD00060686;STK345870;AKOS003242015;CB14952;1,1'-(oxydi-4,1-phenylene)diethanone;NCGC00245566-01;SMR000184606;VS-01856;1-[4-(4-Acetylphenoxy)phenyl]ethanone #;BIM-0011486.P001;CS-0313618;FT-0676286;1,1'-(4,4'-oxybis(4,1-phenylene))diethanone;2-08-00-00085 (Beilstein Handbook Reference);A852167;SR-01000197262;SR-01000197262-1

Chemical Property of 4-Acetylphenyl ether

Chemical Property:

• Melting Point: 103-105°C
• Boiling Point: 409.9 °C at 760 mmHg
• Flash Point: 182.4 °C
• PSA: 43.37000
• Density: 1.139 g/cm³
• LogP: 3.88410
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 254.094294304
• Heavy Atom Count: 19
• Complexity: 289

Purity/Quality:

97% ^*data from raw suppliers

Bis(4-acetylphenyl)ether 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)C(=O)C

Technology Process of 4-Acetylphenyl ether

There total 14 articles about 4-Acetylphenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diphenylether (101-84-8) + acetyl chloride (75-36-5) → 4,4'-oxydiacetophenone (2615-11-4)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 20 ℃;

DOI:10.1023/A:1025759808918

Reference yield: 92.0%

4-acetylphenylboronic acid (149104-90-5) → 4,4'-oxydiacetophenone (2615-11-4)

Guidance literature:

With copper diacetate; water; triethylamine; In dichloromethane; acetonitrile; at 25 ℃; for 6h;

DOI:10.1016/S0040-4039(03)01776-3

Reference yield: 85.0%

4-Iodoacetophenone (13329-40-3) → 4,4'-oxydiacetophenone (2615-11-4)

Guidance literature:

With potassium phosphate; copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; water; In ethanol; at 130 ℃; for 30h; chemoselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201001373

upstream raw materials:

diphenylether

acetyl chloride

bis<4-(1-ethoxyethyl)phenyl> ether

carbon disulfide

Downstream raw materials:

4,4'-oxybis(prop-1-en-2-ylbenzene)

bis<4-(1-hydroxyethyl)phenyl> ether

4,4'-oxybis(ethylbenzene)

2,2'-(oxydibenzene-4 1-diyl)diacetic acid