2H-Pyrazolo[4,3-d]pyrimidin-5-amine, N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen yl)-2-[(4-methoxyphenyl)methyl]-

Base Information

Chemical Name:2H-Pyrazolo[4,3-d]pyrimidin-5-amine, N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen yl)-2-[(4-methoxyphenyl)methyl]-
CAS No.:916065-18-4
Molecular Formula:C29H24ClF4N5O2
Molecular Weight:585.988
Hs Code.:

2H-Pyrazolo[4,3-d]pyrimidin-5-amine,
N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen
yl)-2-[(4-methoxyphenyl)methyl]-

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Chemical Property of 2H-Pyrazolo[4,3-d]pyrimidin-5-amine, N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen yl)-2-[(4-methoxyphenyl)methyl]-

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Technology Process of 2H-Pyrazolo[4,3-d]pyrimidin-5-amine, N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen yl)-2-[(4-methoxyphenyl)methyl]-

There total 11 articles about 2H-Pyrazolo[4,3-d]pyrimidin-5-amine, N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen yl)-2-[(4-methoxyphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 916065-23-1
7-chloro-N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-d]pyrimidine-5-amine

: 916178-96-6
Potassium 2-fluoro-6-methoxyphenyltrifluoroborate

: 916065-18-4
N-[2-Chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphenyl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-d]pyrimidine-5-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; Product distribution / selectivity; Heating / reflux;

Reference yield: 82.0%

: 916065-17-3
N-[2-Chloro-4-(trifluoromethyl)phenyl]-7-(2-fluoro-6-methoxyphenyl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-d]pyrimidine-5-amine

: 75-03-6
ethyl iodide

: 916065-18-4
N-[2-Chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphenyl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-d]pyrimidine-5-amine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 1.03333h; Product distribution / selectivity; Cooling with acetone-ice;

Reference yield: 24.0%

: 916065-23-1
7-chloro-N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-d]pyrimidine-5-amine

: 78495-63-3
(2-fluoro-6-methoxyphenyl)boronic acid

: 916065-18-4
N-[2-Chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphenyl)-2-(4-methoxybenzyl)-2H-pyrazolo[4,3-d]pyrimidine-5-amine

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; Product distribution / selectivity; Heating / reflux;