2'-Deoxy-2'-fluoro-5-iodouridine

Base Information

Chemical Name:2'-Deoxy-2'-fluoro-5-iodouridine
CAS No.:55612-21-0
Molecular Formula:C9H10 F I N2 O5
Molecular Weight:372.092
Hs Code.:
Nikkaji Number:J698.327H
ChEMBL ID:CHEMBL2311087
Mol file:55612-21-0.mol

Synonyms:5-IFDU;5-iodo-1-(2-fluoro-2-deoxy-beta-D-ribofuranosyl)uracil;5-iodo-1-(2-fluoro-2-deoxyribofuranosyl)uracil;5-iodo-1-(2-fluoro-2-deoxyribofuranosyl)uracil, 131I-labeled;5-iodo-1-(2-fluoro-2-deoxyuridine);FIRU cpd

Suppliers and Price of 2'-Deoxy-2'-fluoro-5-iodouridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2’-epi-Fialuridine
25mg
$ 155.00

Crysdot
1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione 97%
1g
$ 1131.00

Chemenu
1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione 97%
1g
$ 1066.00

Total 26 raw suppliers

Chemical Property of 2'-Deoxy-2'-fluoro-5-iodouridine

Chemical Property:

Melting Point:216-218 °C
Boiling Point:°Cat760mmHg
PKA:7.94±0.10(Predicted)
Flash Point:°C
PSA：104.81000
Density:2.18g/cm³
LogP:-0.85780
XLogP3:-0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:371.96185
Heavy Atom Count:18
Complexity:418

Purity/Quality:

99% ^*data from raw suppliers

2’-epi-Fialuridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)F)I
Isomeric SMILES:C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)F)I
Uses An antiviral agent; nucleoside analog with antihepatitis B activity.

Technology Process of 2'-Deoxy-2'-fluoro-5-iodouridine

There total 4 articles about 2'-Deoxy-2'-fluoro-5-iodouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 565226-18-8
((2R,3R,4R,5R)-3-acetoxy-4-fluoro-5-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl acetate

: 55612-21-0
1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione

Guidance literature:: With methanol; ammonia; at 20 ℃; for 20h;
DOI:10.1002/anie.201409803

Reference yield: 94.0%

: 56287-17-3,69123-94-0,784-71-4
2'-deoxy-2'-fluorouridine

: 55612-21-0
1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione

Guidance literature:: With N-iodo-succinimide; In N,N-dimethyl-formamide;

Reference yield:

: 10212-13-2
3’,5’-O-acetyl-2’-deoxy-2’-fluorouridine

: 55612-21-0
1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; ammonium cerium (IV) nitrate / acetonitrile / 1.5 h / 90 °C

2: ammonia; methanol / 20 h / 20 °C

With methanol; ammonium cerium (IV) nitrate; ammonia; iodine; In acetonitrile;
DOI:10.1002/anie.201409803