4-fluoro-N-(4-methylphenyl)benzamide

Base Information

• Chemical Name: 4-fluoro-N-(4-methylphenyl)benzamide
• CAS No.: 399-05-3
• Molecular Formula: C14H12FNO
• Molecular Weight: 229.254
• Mol file: 399-05-3.mol

Synonyms:4-Fluor-benzoesaeure-p-toluidid;4-fluoro-benzoic acid p-toluidide;4-Fluor-benzoesaeure-phenacylamid;4-fluoro-benzoic acid phenacylamide;

Chemical Property of 4-fluoro-N-(4-methylphenyl)benzamide

Chemical Property:

• PSA: 32.59000
• LogP: 3.77040

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-N-(p-tolyl)benzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-fluoro-N-(4-methylphenyl)benzamide

There total 13 articles about 4-fluoro-N-(4-methylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-fluorobenzoyl chloride (403-43-0) + p-toluidine (106-49-0,12221-03-3) → 4-fluoro-N-(4-methylphenyl)benzamide (399-05-3)

Guidance literature:

In neat (no solvent); at 100 ℃; for 0.0833333h;

DOI:10.1080/00397911.2016.1148164

Reference yield: 90.0%

carbon monoxide (201230-82-2) + 1-methyl-4-nitrobenzene (99-99-0) + 4-fluoroboronic acid (1765-93-1) → 4-fluoro-N-(4-methylphenyl)benzamide (399-05-3)

Guidance literature:

With chloro-trimethyl-silane; nickel; triphenylphosphine; sodium iodide; In N,N-dimethyl acetamide; at 135 ℃; for 16h; Schlenk technique; Sealed tube;

DOI:10.1039/c9cc06638a

Reference yield: 81.0%

1-methyl-4-nitrobenzene (99-99-0) + 4-fluorobenzaldehyde (459-57-4) → 4-fluoro-N-(4-methylphenyl)benzamide (399-05-3)

Guidance literature:

With sodium chlorate; acetic acid; zinc; In ethanol; water; at 35 ℃; for 0.75h;

DOI:10.1055/s-0034-1380111

upstream raw materials:

4-fluorobenzoyl chloride

p-toluidine

4-Fluorobenzoic acid

p-fluorobenzamide

Downstream raw materials:

2-amino-5-methylphenyl 4-fluorophenyl ketone

5-methyl-2-(4'-fluoro)phenyl-1H-indole