1,1-Cyclopropanedicarboxamide

Base Information

• Chemical Name: 1,1-Cyclopropanedicarboxamide
• CAS No.: 5813-85-4
• Molecular Formula: C5H8 N2 O2
• Molecular Weight: 128.131
• European Community (EC) Number: 611-629-0
• NSC Number: 171670
• DSSTox Substance ID: DTXSID00305784
• Nikkaji Number: J480.654I
• Wikidata: Q82052522
• Mol file: 5813-85-4.mol

Synonyms:1,1-Cyclopropanedicarboxamide;cyclopropane-1,1-dicarboxamide;5813-85-4;NSC 171670;NSC171670;SCHEMBL196273;DTXSID00305784;AKOS006338464;DCL000409(XL184);NSC-171670

Chemical Property of 1,1-Cyclopropanedicarboxamide

Chemical Property:

• Vapor Pressure: 7.1E-10mmHg at 25°C
• Boiling Point: 493.3°Cat760mmHg
• Flash Point: 252.2°C
• Density: 1.447g/cm³
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 128.058577502
• Heavy Atom Count: 9
• Complexity: 156

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1(C(=O)N)C(=O)N

Technology Process of 1,1-Cyclopropanedicarboxamide

There total 9 articles about 1,1-Cyclopropanedicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.9%

cyclopropane-1,1-dicarbonitrile (1559-03-1) → cyclopropane-1,1-dicarboxylic acid amide [4-(3-fluoro-benzyloxy)-phenyl]-amide (5813-85-4)

Guidance literature:

With water; tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; In dichloromethane; at 55 - 60 ℃; for 12h; Reagent/catalyst; Temperature;

Reference yield: 42.0%

4-(3-fluoro-phenoxymethyl)-phenylamine (630412-79-2) + 1-aminocarbonylcyclopropanecarboxylic acid (6914-74-5) → cyclopropane-1,1-dicarboxylic acid amide [4-(3-fluoro-benzyloxy)-phenyl]-amide (5813-85-4)

Guidance literature:

Reference yield:

diethyl ether (60-29-7,927820-24-4) + diethyl 2-(2-bromoethyl)-malonate (18721-64-7) + ammonia (7664-41-7) → Cyclopropan-1-carbonsaeureethylester-1-carbonsaeureamid (6914-75-6) + diethyl cyclopropane-1,1-dicarboxylate (1559-02-0) + cyclopropane-1,1-dicarboxylic acid amide [4-(3-fluoro-benzyloxy)-phenyl]-amide (5813-85-4)

Guidance literature:

upstream raw materials:

ethanol

N,N'-dibromo-cyclopropane-1,1-dicarboxamide

Cyclopropan-1-carbonsaeureethylester-1-carbonsaeureamid

diethyl cyclopropane-1,1-dicarboxylate

Downstream raw materials:

ethyl propanediamide

cabozantinib