(6Z)-6-[(hydroxyamino)methylidene]cyclohexa-2,4-dien-1-one - copper (2:1)

Base Information

Chemical Name:(6Z)-6-[(hydroxyamino)methylidene]cyclohexa-2,4-dien-1-one - copper (2:1)
CAS No.:14363-26-9
Molecular Formula:C₁₄H₁₂CuN₂O₄
Molecular Weight:335.806
Hs Code.:

Synonyms:Copper,bis(2-hydroxybenzaldehyde oximato-N1,O2)-; Copper, bis(salicylaldehydeoximato)- (6CI,7CI,8CI); Benzaldehyde, 2-hydroxy-, oxime, copper complex;Bis(salicylaldehyde oximato)copper; Bis(salicylaldoximato)copper; Copper(II)salicylaldoximate; NSC 166010

Suppliers and Price of (6Z)-6-[(hydroxyamino)methylidene]cyclohexa-2,4-dien-1-one - copper (2:1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6Z)-6-[(hydroxyamino)methylidene]cyclohexa-2,4-dien-1-one - copper (2:1)

Chemical Property:

Vapor Pressure:0.000162mmHg at 25°C
Boiling Point:295.1°Cat760mmHg
Flash Point:132.3°C
Density:g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

General Description (6Z)-6-[(hydroxyamino)methylidene]cyclohexa-2,4-dien-1-one - copper (2:1), also known as bis(salicylaldoximato)copper(II) or CuSAL, is a paramagnetic copper(II) complex that exhibits significant spin delocalization onto the organic ligand, leading to large paramagnetic NMR shifts. It demonstrates potent anti-leishmanial activity by selectively inhibiting *Leishmania donovani* topoisomerase IB, inducing apoptosis through reactive oxygen species generation and caspase-like protease activation, while showing minimal toxicity to human cells. The complex's paramagnetic properties and spin distribution make it a sensitive probe for NMR studies, with computational models supporting its structural and electronic behavior.

Technology Process of (6Z)-6-[(hydroxyamino)methylidene]cyclohexa-2,4-dien-1-one - copper (2:1)

There total 12 articles about (6Z)-6-[(hydroxyamino)methylidene]cyclohexa-2,4-dien-1-one - copper (2:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 94-67-7
salicylaldehyde-oxime

: 6046-93-1
copper(II) acetate monohydrate

: 41942-15-8,14363-26-9
trans-bis(salicylaldoximato)copper(II)

Guidance literature:: In ethanol; acetic acid; addn. of a soln. of salicylaldoxime in EtOH to a soln. of Cu acetate indilute acetic acid; recrystn. from EtOH, elem. anal.;

Reference yield: 74.55%

: copper(II) choride dihydrate

: 94-67-7
salicylaldehyde-oxime

: 14363-26-9,41942-15-8
bis(salicylaldoximato)copper(II)

Guidance literature:: With potassium hydroxide; In ethanol; Reflux;
DOI:10.13005/ojc/320620

Reference yield: 74.0%

: 94-67-7
salicylaldehyde-oxime

: copper dichloride

: 41942-15-8,14363-26-9
trans-bis(salicylaldoximato)copper(II)

Guidance literature:: With hydrochloric acid; In ethanol; water; addn. of an slightly acidified aq. soln. of CuCl2 to an ethanolic soln. of the oxime with stirring; filtration, recrystn. from chloroform/ether, elem. anal.;
DOI:10.1016/S0277-5387(00)86011-8