5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Base Information

Chemical Name:5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one
CAS No.:150322-39-7
Molecular Formula:C₁₈H₁₈FNO₂S*ClH
Molecular Weight:367.872
Hs Code.:

Synonyms:5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

Chemical Property:

Vapor Pressure:1.65E-09mmHg at 25°C

Purity/Quality:: 99%13C ^*data from raw suppliers

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Technology Process of 5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one

There total 14 articles about 5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1243654-57-0
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide

: 150322-39-7
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride

Guidance literature:: 5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine hydrobromide; With ammonia; In dichloromethane; water; at 0 - 30 ℃;

With hydrogenchloride; In ethyl acetate; acetone; at 25 - 30 ℃; for 1h;

Reference yield:

: 204205-33-4
2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone

: 115473-15-9
5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride

: 150322-39-7
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride

Guidance literature:: 5,6,7,7a-tetrahydro-thieno[3,2-c]pyridin-2(4H)-one hydrochloride; With potassium carbonate; In acetonitrile; at 25 - 30 ℃; for 0.5h;

2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone; In acetonitrile; at 25 - 30 ℃; for 7h;

With hydrogenchloride; In ethyl acetate; acetone; at 25 - 30 ℃; for 1h;

Reference yield:

: 946402-23-9
2-(2-fluorophenyl)-N-methoxy-N-methylacetamide

: 150322-39-7
5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydro thieno[3,2-c] pyridine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C

1.2: 40 - 50 °C

1.3: 0.25 h / 0 - 30 °C

2.1: toluene-4-sulfonic acid; 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 4 h / Reflux

3.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

4.2: 1 h / -78 °C

4.3: 1 h / -60 - 0 °C

5.1: hydrogen bromide / water; acetone / 1 h / 0 - 5 °C

6.1: ammonia / dichloromethane; water / 0 - 30 °C

6.2: 1 h / 25 - 30 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; hydrogen bromide; iodine; potassium carbonate; toluene-4-sulfonic acid; magnesium; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; chloroform; water; acetone; acetonitrile;