5,6-Bis(4-chlorophenyl)-2,3-dihydropyrazine

Base Information

• Chemical Name: 5,6-Bis(4-chlorophenyl)-2,3-dihydropyrazine
• CAS No.: 92405-76-0
• Molecular Formula: C16H12Cl2N2
• Molecular Weight: 303.191
• DSSTox Substance ID: DTXSID60524510
• Wikidata: Q82391421
• Mol file: 92405-76-0.mol

Synonyms:92405-76-0;5,6-Bis(4-chlorophenyl)-2,3-dihydropyrazine;DTXSID60524510

Chemical Property of 5,6-Bis(4-chlorophenyl)-2,3-dihydropyrazine

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 302.0377538
• Heavy Atom Count: 20
• Complexity: 351

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN=C(C(=N1)C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl

Technology Process of 5,6-Bis(4-chlorophenyl)-2,3-dihydropyrazine

There total 2 articles about 5,6-Bis(4-chlorophenyl)-2,3-dihydropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,4'-dichlorobenzil (3457-46-3,88372-92-3) + ethylenediamine (107-15-3,85404-18-8) → 5,6-bis(p-chlorophenyl)-2,3-dihydropyrazine (92405-76-0)

Guidance literature:

With amberlyst-15; In water; at 70 ℃; for 0.183333h;

DOI:10.1080/00397910903219401

Reference yield:

4,4'-dichlorobenzoin (4254-20-0) → 5,6-bis(p-chlorophenyl)-2,3-dihydropyrazine (92405-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ytterbium(III) chloride / ethanol / Reflux

2: dihydrogen peroxide / ethanol / 0.5 h / Reflux

With ytterbium(III) chloride; dihydrogen peroxide; In ethanol;

DOI:10.1016/j.tetlet.2012.11.005

Reference yield: 72.0%

5,6-bis(p-chlorophenyl)-2,3-dihydropyrazine (92405-76-0) → 2,3-bis(p-chlorophenyl)pyrazine (92405-80-6)

Guidance literature:

With sulfur; at 140 ℃; for 0.5h;

upstream raw materials:

4,4'-dichlorobenzil

ethylenediamine

4,4'-dichlorobenzoin

Downstream raw materials:

2,3-bis(p-chlorophenyl)pyrazine

2,3-bis(p-chlorophenyl)pyrazine 1,4-dioxide

2,3-bis(p-chlorophenyl)pyrazine 1-oxide

5,6-bis(p-chlorophenyl)-2,3-diacetoxy-2,3-dihydropyrazine