3-Hydroxy-2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)propan-1-one

Base Information

• Chemical Name: 3-Hydroxy-2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)propan-1-one
• CAS No.: 92409-23-9
• Molecular Formula: C17H18O5
• Molecular Weight: 302.327
• Mol file: 92409-23-9.mol

Synonyms:

Chemical Property of 3-Hydroxy-2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)propan-1-one

Chemical Property:

• Boiling Point: 494.7±45.0 °C(Predicted)
• PKA: 13.67±0.10(Predicted)
• PSA: 0.00000
• Density: 1.200±0.06 g/cm3(Predicted)
• LogP: 0.00000
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Hydroxy-2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Hydroxy-2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)propan-1-one

There total 21 articles about 3-Hydroxy-2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)-1-hydroxy-3-propanol (92409-15-9) → 3-hydroxy-2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)propan-1-one (92409-23-9)

Guidance literature:

With C₂₆H₅₁N₂O₂⁽¹⁺⁾*BF₄^(1-); silica gel; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/ja4113462

Reference yield: 83.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethan-1-one (19513-80-5) → 3-hydroxy-2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)propan-1-one (92409-23-9)

Guidance literature:

With potassium carbonate; In ethanol; water; acetone; at 20 ℃; for 2.5h;

DOI:10.1039/d0gc04231e

Reference yield: 43.0%

2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)-1-hydroxy-3-propanol (92409-15-9) → 3-hydroxy-2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)propan-1-one (92409-23-9) + 4-methoxy-benzaldehyde (123-11-5)

Guidance literature:

With sodium persulfate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; palladium diacetate; In N,N-dimethyl-formamide; at 20 ℃; for 15h; chemoselective reaction; Irradiation;

DOI:10.1021/acs.orglett.6b02651

upstream raw materials:

2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)-1-hydroxy-3-propanol

1-(3,4-dimethoxyphenyl)-2-(methoxyphenoxy)propane-1,3-diol

1-(4-(benzyloxy)-3,5-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol

3-(3,4-dimethoxyphenyl)-3-ethoxy-2-(2-methoxyphenoxy)propan-1-ol

Downstream raw materials:

2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)-1-hydroxy-3-propanol

2-methoxy-phenol

1-(2-methoxyphenoxy)propan-2-one

1-(4-methoxyphenyl)ethanone