6-Benzothiazolecarboxylic acid, 2-amino-4-fluoro-, methyl ester

Base Information

• Chemical Name: 6-Benzothiazolecarboxylic acid, 2-amino-4-fluoro-, methyl ester
• CAS No.: 924287-64-9
• Molecular Formula: C₉H₇FN₂O₂S
• Molecular Weight: 226.231
• Mol file: 924287-64-9.mol

Synonyms:6-Benzothiazolecarboxylic acid,2-aMino-4-fluoro-,Methyl ester;QC-1606;

Chemical Property of 6-Benzothiazolecarboxylic acid, 2-amino-4-fluoro-, methyl ester

Chemical Property:

• Boiling Point: 390℃
• Flash Point: 190℃
• PSA: 94.18000
• Density: 1.501
• LogP: 1.73430

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-amino-4-fluoro-1,3-benzothiazole-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Benzothiazolecarboxylic acid, 2-amino-4-fluoro-, methyl ester

There total 5 articles about 6-Benzothiazolecarboxylic acid, 2-amino-4-fluoro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.4%

→ methyl 2-amino-4-fluoro-1,3-benzothiazole-6-carboxylate (924287-64-9)

Guidance literature:

With bromine; acetic acid; at 10 - 20 ℃;

Reference yield: 68.0%

sodium thiocyanide (540-72-7) + methyl 4-amino-3-fluorobenzene carboxylate (185629-32-7) → methyl 2-amino-4-fluoro-1,3-benzothiazole-6-carboxylate (924287-64-9)

Guidance literature:

With bromine; acetic acid; at 0 - 20 ℃; for 24h;

DOI:10.1021/acs.jmedchem.0c01065

Reference yield: 64.0%

potassium thioacyanate (333-20-0) + methyl 4-amino-3-fluorobenzene carboxylate (185629-32-7) → methyl 2-amino-4-fluoro-1,3-benzothiazole-6-carboxylate (924287-64-9)

Guidance literature:

With bromine; acetic acid; at 20 - 150 ℃; for 50h;

upstream raw materials:

potassium thioacyanate

methyl 4-amino-3-fluorobenzene carboxylate

sodium thiocyanide

methyl 3-fluoro-4-nitrobenzoate

Downstream raw materials:

methyl-2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate

2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid

C₂₉H₂₆F₄N₄O₄S

methyl 2-bromo-4-fluoro-1,3-benzothiazole-6-carboxylate