1H-Pyrazolo[3,4-b]pyridine, 4-chloro-1-[(4-methoxyphenyl)methyl]-

Base Information

• Chemical Name: 1H-Pyrazolo[3,4-b]pyridine, 4-chloro-1-[(4-methoxyphenyl)methyl]-
• CAS No.: 924909-17-1
• Molecular Formula: C14H12ClN3O
• Molecular Weight: 273.722
• Mol file: 924909-17-1.mol

Synonyms:4-chloro-1H-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine;

Chemical Property of 1H-Pyrazolo[3,4-b]pyridine, 4-chloro-1-[(4-methoxyphenyl)methyl]-

Chemical Property:

• PSA: 39.94000
• LogP: 3.14160

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazolo[3,4-b]pyridine, 4-chloro-1-[(4-methoxyphenyl)methyl]-

There total 8 articles about 1H-Pyrazolo[3,4-b]pyridine, 4-chloro-1-[(4-methoxyphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol (924909-16-0,370866-00-5) → 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine (924909-17-1)

Guidance literature:

With trichlorophosphate; In dichloromethane; Reflux; Inert atmosphere;

Reference yield:

[[[1-[(4-Methoxyphenyl)methyl]-1H-pyrazol-5-yl]amino]methylene]propanedioic acid diethyl ester → 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine (924909-17-1)

Guidance literature:

Multi-step reaction with 4 steps

1: diphenylether / 3 h / 250 °C / Inert atmosphere

2: sodium hydroxide; ethanol / Inert atmosphere

3: diphenylether / 1 h / 120 °C / Inert atmosphere

4: trichlorophosphate / 2 h / 60 °C / Inert atmosphere

With ethanol; sodium hydroxide; trichlorophosphate; In diphenylether;

Reference yield:

4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (227617-15-4) → 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine (924909-17-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; ethanol / Inert atmosphere

2: diphenylether / 1 h / 120 °C / Inert atmosphere

3: trichlorophosphate / 2 h / 60 °C / Inert atmosphere

With ethanol; sodium hydroxide; trichlorophosphate; In diphenylether;

upstream raw materials:

1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-ol

1-(4-methoxybenzyl)-1H-pyrazol-5-amine

5-(((1-(4-methoxybenzyl)-1H-pyrazol-5-yl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

4-methoxy-benzaldehyde

Downstream raw materials:

4-Chloro-1H-pyrazolo<3,4-b>pyridine

3-bromo-4-chloro-1H-pyrazolo[3,4-b]pyridine

4-chloro-3-iodo-1H-pyrazolo[3,4-b]pyridine

4-chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3 ,4-b]pyridine