NU1025

Base Information

• Chemical Name: NU1025
• CAS No.: 90417-38-2
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.175
• Hs Code.: 29335990
• Mol file: 90417-38-2.mol

Synonyms:4(1H)-Quinazolinone,8-hydroxy-2-methyl- (9CI); NSC 696807; Nu 1025

Chemical Property of NU1025

Chemical Property:

• Vapor Pressure: 3.09E-05mmHg at 25°C
• Melting Point: 253-258掳C
• Boiling Point: 345.4°Cat760mmHg
• Flash Point: 162.7°C
• PSA: 65.98000
• Density: 1.42g/cm³
• LogP: 0.93710
• Storage Temp.: −20°C
• Solubility.: DMSO: 35 mg/mL, soluble

Purity/Quality:

97% ^*data from raw suppliers

NU 1025 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.
• Uses: NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical] A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.

Technology Process of NU1025

There total 10 articles about NU1025 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

8-methoxy-2-methyl-4-oxo-3,4-dihydroquinazoline (90915-45-0) → 8-hydroxy-2-methyl-4(3H)-quinazolinone (90417-38-2)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 2h; Reflux;

DOI:10.1016/j.tetlet.2016.08.018

Reference yield:

3-methoxy-2-aminobenzamide (106782-78-9) → 8-hydroxy-2-methyl-4(3H)-quinazolinone (90417-38-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 31 percent / pyridine / tetrahydrofuran / 25 °C

2: 67 percent / aq. NaOH / Ambient temperature

3: 65 percent / BBr₃ / CH₂Cl₂ / Heating

With pyridine; sodium hydroxide; boron tribromide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm980273t

Reference yield:

2-N-Acetylamino-3-methoxybenzamide (172462-98-5) → 8-hydroxy-2-methyl-4(3H)-quinazolinone (90417-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / aq. NaOH / Ambient temperature

2: 65 percent / BBr₃ / CH₂Cl₂ / Heating

With sodium hydroxide; boron tribromide; In dichloromethane;

DOI:10.1021/jm980273t

upstream raw materials:

8-methoxy-2-methyl-4-oxo-3,4-dihydroquinazoline

8-methoxy-quinazolin-4(3H)-one

3-methoxy-2-aminobenzamide

2-N-Acetylamino-3-methoxybenzamide

Downstream raw materials:

4-chloro-8-hydroxy-2-methyl-quinazoline