3-(3-Hydroxymethylphenyl)isonicotinic acid

Base Information

• Chemical Name: 3-(3-Hydroxymethylphenyl)isonicotinic acid
• CAS No.: 928148-47-4
• Molecular Formula: C13H11NO3
• Molecular Weight: 229.235
• Mol file: 928148-47-4.mol

Synonyms:5-(3-Hydroxymethylphe;5-[4-(hydroxymethyl)phenyl]-3-pyridinecarboxylic acid;5-(4-Hydroxymethylphenyl)nicotinic acid;3-(4-Hydroxymethylphenyl)isonicotinic acid;

Chemical Property of 3-(3-Hydroxymethylphenyl)isonicotinic acid

Chemical Property:

• PSA: 70.42000
• LogP: 1.93910

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-Hydroxymethylphenyl)isonicotinic acid

There total 1 articles about 3-(3-Hydroxymethylphenyl)isonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-3-pyridinecarboxylic acid (20826-04-4) + p-hydroxymethylphenylboronic acid (59016-93-2) → 5-[4-(hydroxymethyl)phenyl]-3-pyridinecarboxylic acid (928148-47-4)

Guidance literature:

5-bromo-3-pyridinecarboxylic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 20 ℃; for 0.25h;

p-hydroxymethylphenylboronic acid; With sodium carbonate; In 1,2-dimethoxyethane; water; at 95 ℃; for 16h;

DOI:10.1021/jm100556b

Reference yield:

1-methyl-piperazine (109-01-3) + 5-[4-(hydroxymethyl)phenyl]-3-pyridinecarboxylic acid (928148-47-4) + 6-(1-cyclopentylhydrazino)-9-methyl-9H-purine-2-carbonitrile (1055926-65-2) → N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide (1055925-50-2)

Guidance literature:

5-[4-(hydroxymethyl)phenyl]-3-pyridinecarboxylic acid; With oxalyl dichloride; In dichloromethane; at 20 ℃;

6-(1-cyclopentylhydrazino)-9-methyl-9H-purine-2-carbonitrile; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

1-methyl-piperazine; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

5-[4-(hydroxymethyl)phenyl]-3-pyridinecarboxylic acid (928148-47-4) → 5-[4-(chloromethyl)phenyl]-3-pyridinecarbonyl chloride

Guidance literature:

With thionyl chloride; for 2h; Reflux;

DOI:10.1021/jm100556b

upstream raw materials:

5-bromo-3-pyridinecarboxylic acid

p-hydroxymethylphenylboronic acid

Downstream raw materials:

N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide

N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide trifluoroacetate