N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide trifluoroacetate

Base Information

• Chemical Name: N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide trifluoroacetate
• CAS No.: 1055925-51-3
• Molecular Formula: C₂HF₃O₂*C₃₀H₃₄N₁₀O
• Molecular Weight: 664.69
• Mol file: 1055925-51-3.mol

Synonyms:

Chemical Property of N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide trifluoroacetate

There total 12 articles about N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide (1055925-50-2) + trifluoroacetic acid (76-05-1) → N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide trifluoroacetate (1055925-51-3)

Guidance literature:

In water; acetonitrile;

Reference yield:

5-bromo-3-pyridinecarboxylic acid (20826-04-4) → N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide trifluoroacetate (1055925-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 20 °C

1.2: 21 h / 95 °C / Heating / reflux

1.3: pH 3

2.1: oxalyl dichloride / dichloromethane / 20 °C

2.2: 20 °C

2.3: 72 h / 20 °C

3.1: water; acetonitrile

With oxalyl dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;

Reference yield:

1,1-dimethylethyl 2-[2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]-2-cyclopentylhydrazinecarboxylate (1055926-56-1) → N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide trifluoroacetate (1055925-51-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 0.05 h / 150 °C / 9000.9 Torr / Microwave irradiation

2.1: dowex D-50 (H+) / ethanol / 1 h / Heating / reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C

4.1: toluene-4-sulfonic acid / acetonitrile / 20 °C

5.1: oxalyl dichloride / dichloromethane / 20 °C

5.2: 20 °C

5.3: 72 h / 20 °C

6.1: water; acetonitrile

With 1,1'-bis-(diphenylphosphino)ferrocene; oxalyl dichloride; potassium carbonate; toluene-4-sulfonic acid; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide

trifluoroacetic acid

5-bromo-3-pyridinecarboxylic acid

5-[4-(hydroxymethyl)phenyl]-3-pyridinecarboxylic acid