N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide

Base Information

Chemical Name:N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide
CAS No.:1055925-50-2
Molecular Formula:C₃₀H₃₄N₁₀O
Molecular Weight:550.666
Hs Code.:

Synonyms:N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide

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Chemical Property of N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide

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Technology Process of N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide

There total 11 articles about N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 928148-47-4
5-[4-(hydroxymethyl)phenyl]-3-pyridinecarboxylic acid

: 1055926-65-2
6-(1-cyclopentylhydrazino)-9-methyl-9H-purine-2-carbonitrile

: 1055925-50-2
N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide

Guidance literature:: 5-[4-(hydroxymethyl)phenyl]-3-pyridinecarboxylic acid; With oxalyl dichloride; In dichloromethane; at 20 ℃;

6-(1-cyclopentylhydrazino)-9-methyl-9H-purine-2-carbonitrile; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

1-methyl-piperazine; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

: 20826-04-4
5-bromo-3-pyridinecarboxylic acid

: 1055925-50-2
N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 20 °C

1.2: 21 h / 95 °C / Heating / reflux

1.3: pH 3

2.1: oxalyl dichloride / dichloromethane / 20 °C

2.2: 20 °C

2.3: 72 h / 20 °C

With oxalyl dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 1055926-56-1
1,1-dimethylethyl 2-[2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]-2-cyclopentylhydrazinecarboxylate

: 1055925-50-2
N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-5-{4-[(4-methyl-1-piperazinyl)methyl]phenyl}-3-pyridinecarbohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 0.05 h / 150 °C / 9000.9 Torr / Microwave irradiation

2.1: dowex D-50 (H+) / ethanol / 1 h / Heating / reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C

4.1: toluene-4-sulfonic acid / acetonitrile / 20 °C

5.1: oxalyl dichloride / dichloromethane / 20 °C

5.2: 20 °C

5.3: 72 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; oxalyl dichloride; potassium carbonate; toluene-4-sulfonic acid; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ethanol; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetonitrile;