1H-Pyrrole-1-carboxylic acid, 4-(4-chlorophenyl)-2,5-dihydro-2-oxo-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Pyrrole-1-carboxylic acid, 4-(4-chlorophenyl)-2,5-dihydro-2-oxo-, 1,1-dimethylethyl ester
CAS No.:928215-97-8
Molecular Formula:C15H16ClNO3
Molecular Weight:293.75
Hs Code.:

Synonyms:4-(4-chloro-phenyl)-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester;1-Boc-4-(4-chlorophenyl)-1H-pyrrol-2(5H)-one;tert-butyl 4-(4-chlorophenyl)-2,5-dihydro-2-oxo-1H-pyrrole-1-carboxylate;

Suppliers and Price of 1H-Pyrrole-1-carboxylic acid, 4-(4-chlorophenyl)-2,5-dihydro-2-oxo-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl4-(4-chlorophenyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate 95+%
1g
$ 1122.00

Chemenu
tert-Butyl4-(4-chlorophenyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate 95%
1g
$ 1057.00

AK Scientific
tert-butyl3-(4-chlorophenyl)-5-oxo-2H-pyrrole-1-carboxylate
1g
$ 1270.40

AK Scientific
tert-butyl3-(4-chlorophenyl)-5-oxo-2H-pyrrole-1-carboxylate
250mg
$ 659.60

Total 6 raw suppliers

Chemical Property of 1H-Pyrrole-1-carboxylic acid, 4-(4-chlorophenyl)-2,5-dihydro-2-oxo-, 1,1-dimethylethyl ester

Chemical Property:

Melting Point:172 - 173 °C
PSA：46.61000
LogP:3.43860

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(4-chlorophenyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-1-carboxylic acid, 4-(4-chlorophenyl)-2,5-dihydro-2-oxo-, 1,1-dimethylethyl ester

There total 3 articles about 1H-Pyrrole-1-carboxylic acid, 4-(4-chlorophenyl)-2,5-dihydro-2-oxo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1679-18-1
4-Chlorophenylboronic acid

: 443680-33-9
2-oxo-4-(toluene-4-sulfonyloxy)-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester

: 928215-97-8
4-(4-chlorophenyl)-2-oxo-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; Heating;
DOI:10.1016/j.tetlet.2006.11.156

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 141293-14-3
N-(tert-butoxycarbonyl)pyrrol-2(5H)-one

: 928215-97-8
4-(4-chlorophenyl)-2-oxo-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester

: 1-Boc-4-(4-chlorophenyl)-pyrrolidin-2-one

Guidance literature:: 4-Chlorophenylboronic acid; N-(tert-butoxycarbonyl)pyrrol-2(5H)-one; With chlorobis(ethylene)rhodium(I) dimer; (S,E)-4-isopropyl-2-(1-styryl-1H-indol-2-yl)-4,5-dihydrooxazole; potassium hydroxide; In 1,4-dioxane; water; at 70 ℃; for 24h; Inert atmosphere;

With ammonium chloride; In 1,4-dioxane; water; optical yield given as %ee; enantioselective reaction; Saturated solution;
DOI:10.1016/j.tet.2012.01.040

Reference yield:

: 182352-48-3
2-oxo-4-pent-4-enyloxy-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 928215-97-8
4-(4-chlorophenyl)-2-oxo-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / DIEA / CH₂Cl₂

2: 90 percent / cesium carbonate / Pd(dppf)Cl₂ / tetrahydrofuran; H₂O / Heating

With caesium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; water; 2: Suzuki reaction;
DOI:10.1016/j.tetlet.2006.11.156