3,5-Dichloropropiophenone

Base Information

• Chemical Name: 3,5-Dichloropropiophenone
• CAS No.: 92821-92-6
• Molecular Formula: C₉H₈Cl₂O
• Molecular Weight: 203.068
• Mol file: 92821-92-6.mol

Synonyms:

Chemical Property of 3,5-Dichloropropiophenone

Chemical Property:

• Boiling Point: 299℃
• Flash Point: 125℃
• Density: 1.258
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-(3,5-Dichloro-phenyl)-propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dichloropropiophenone

There total 5 articles about 3,5-Dichloropropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

ethylmagnesium chloride (2386-64-3) + 3,5-dichloro-N-methoxy-N-methylbenzamide (259796-12-8) → 1-(3,5-dichlorophenyl)propan-1-one (92821-92-6)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 80.0%

3,5-dichlorobenzonitrile (6575-00-4) + ethylmagnesium chloride (2386-64-3) → 1-(3,5-dichlorophenyl)propan-1-one (92821-92-6)

Guidance literature:

3,5-dichlorobenzonitrile; ethylmagnesium chloride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃;

DOI:10.1021/jm901189z

Reference yield:

3,5-dichlorobenzoic acid (51-36-5) → 1-(3,5-dichlorophenyl)propan-1-one (92821-92-6)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 5 h / Reflux

2: pyridine / dichloromethane / 12 h / 20 °C

3: tetrahydrofuran / 0 - 20 °C

With pyridine; thionyl chloride; In tetrahydrofuran; dichloromethane;

upstream raw materials:

3,5-dichlorobenzonitrile

ethylmagnesium chloride

ethylmagnesium bromide

3,5-dichloro-N-methoxy-N-methylbenzamide

Refernces

• 1、 -. "MONOAM1NE REUPTAKE INHIBITORS". Page/Page column 73. . Retrieved 2010/11/04.
• 2、 Carroll, F. Ivy,Blough, Bruce E.,Abraham, Philip,Mills, Andrew C.,Holleman, J. Ashley,Wolckenhauer, Scott A.,Decker, Ann M.,Landavazo, Antonio,McElroy, K. Timothy,Navarro, Hernán A.,Gatch, Michael B.,Forster, Michael J.. "Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction". supporting information; experimental part. p. 6768 - 6781. Retrieved 2010/04/06.