259796-12-8

Usage

Uses

Used in Pharmaceutical Research:
3,5-dichloro-N-Methoxy-N-MethylbenzaMide is used as a building block in pharmaceutical research for the development of various drugs and biologically active compounds. Its unique chemical structure allows it to be a versatile component in the synthesis of new molecules with potential therapeutic applications.
Used in Organic Synthesis:
3,5-dichloro-N-Methoxy-N-MethylbenzaMide is used as a key intermediate in organic synthesis, enabling the creation of a wide range of chemical compounds. Its reactivity and functional groups make it a valuable component in the synthesis of complex organic molecules.
Used in Disease Treatment Research:
3,5-dichloro-N-Methoxy-N-MethylbenzaMide is used in research aimed at developing treatments for certain diseases and conditions. Its potential applications in this area are still under investigation, but its unique properties make it a promising candidate for further study.
Used in Analgesic and Anti-Inflammatory Drug Development:
3,5-dichloro-N-Methoxy-N-MethylbenzaMide is used as a candidate for the development of analgesic and anti-inflammatory drugs due to its mild analgesic and anti-inflammatory properties. Its potential in this area is currently being explored for the creation of new medications to treat pain and inflammation.

Upstream product

• 1117-97-1 N,0-dimethylhydroxylamine 
• 2905-62-6 3,5-dichlorobenzoyl chloride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 51-36-5 3,5-dichlorobenzoic acid 

Downstream Products

• 14401-72-0 3',5'-dichloroacetophenone 
• 844879-42-1 (3-bromophenyl)-(3,5-dichlorophenyl)methanone 
• 920032-86-6 (5-bromopyridin-2-yl)-(3,5-dichlorophenyl)methanone 
• 92821-92-6 1-(3,5-dichlorophenyl)propan-1-one 
• 10203-08-4 3,5-dichlorobenzaldehyde 
• 73075-58-8 5,7-dichloro isoquinoline 
• 89315-56-0 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Preparation method of 5, 7-dichloro-1, 2, 3, 4-tetrahydroisoquinoline

The invention provides a preparation method of 5, 7-dichloro-1, 2, 3, 4-tetrahydroisoquinoline. The preparation method comprises the following steps: preparing a compound A by taking 3, 5-dichlorobenzoic acid as a raw material; preparing a compound B from the compound A; preparing a compound C from the compound B; preparing a compound D from the compound C; and obtaining a white solid 5, 7-dichloro-1, 2, 3, 4-tetrahydroisoquinoline from the compound D. The preparation method of 5, 7-dichloro-1, 2, 3, 4-tetrahydroisoquinoline provided by the invention has the advantages of high product purity and high product yield.

N-(Substituted sulfonyl)benzamide derivative and preparation method and pharmaceutical application thereof

The invention relates to an N-(substituted sulfonyl)benzamide derivative and preparation method and pharmaceutical application thereof, in particular to an N-(substituted sulfonyl)benzamide derivativeshown as general formula (I), preparation method thereof, medicinal salts of the derivative, and their application as therapeutics, especially as Nav1.7 inhibitors, wherein substituents in the general formula (I) shown in the description are defined the same as in the description.

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

A small library of 36 functionalized benzophenone thiosemicarbazone analogs has been prepared by chemical synthesis and evaluated for their ability to inhibit the cysteine proteases cathepsin L and cathepsin B. Inhibitors of cathepsins L and B have the potential to limit or arrest cancer metastasis. The six most active inhibitors of cathepsin L (IC50 50 > 10,000 nM). The most active analog in the series, 3-bromophenyl-2′-fluorophenyl thiosemicarbazone 1, also efficiently inhibits cell invasion of the DU-145 human prostate cancer cell line.

Quinazoline derivatives useful in cancer treatment

The present invention provides compounds of Formula I (wherein R1, R2, R3, L, and X are as defined herein). [image] or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compound

SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE

The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes

A ROMPGEL-supported N-hydroxysuccinimide: A host of acylations with minimal purification

(formula presented) amides, carbamates, ureas, Weinreb amides, hydroxamic acids Yields 89-98% Purity > 95% A novel N-hydroxysuccinimide ring-opening metathesis polymer is described as a recyclable supported acyl transfer reagent. Amides, carbamates, ureas, Weinreb amides, and hydroxamic acids are all obtained in excellent yields and purities from amines with minimal purification.