D-Glutamic acid, bis(1,1-dimethylethyl) ester

Base Information

Chemical Name:D-Glutamic acid, bis(1,1-dimethylethyl) ester
CAS No.:92837-84-8
Molecular Formula:C13H25NO4
Molecular Weight:259.346
Hs Code.:

Synonyms:D-Glu(OtBu)OtBu;di-tert-butyl (2R)-2-aminopentanedioate;(2R)-di-tert-butyl glutamate;(R)-di-tert-butyl 2-aminopentanedioate;di-tert-butyl D-glutamate;H-D-Glu(OtBu)2;(R)-2-Amino-pentanedioic acid di-tert-butyl ester;

Suppliers and Price of D-Glutamic acid, bis(1,1-dimethylethyl) ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of D-Glutamic acid, bis(1,1-dimethylethyl) ester

Chemical Property:

Boiling Point:311.1±27.0 °C(Predicted)
PSA：78.62000
Density:1.020±0.06 g/cm3(Predicted)
LogP:2.47760

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of D-Glutamic acid, bis(1,1-dimethylethyl) ester

There total 1 articles about D-Glutamic acid, bis(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86491-34-1
Di-tert-butyl α-ketoglutarate

: 16874-06-9
di-tert-butyl L-glutamate

: 92837-84-8
di-tert-butyl (2R)-2-aminopentanedioate

Guidance literature:: Di-tert-butyl α-ketoglutarate; With p-nitrobenzylamine; C₅₀H₃₄F₆NO₂⁽¹⁺⁾*C₁₀H₁₁O₂^(1-); In 1,3,5-trimethyl-benzene; at 20 ℃; for 48h; Molecular sieve;

With hydrogenchloride; In tetrahydrofuran; water; 1,3,5-trimethyl-benzene; at 0 ℃; for 1h; enantioselective reaction;
DOI:10.1021/acs.orglett.9b00588

Reference yield: 81.0%

: 7398-42-7
methyl 2-(4-(bromomethyl)phenyl)acetate

: 92837-84-8
di-tert-butyl (2R)-2-aminopentanedioate

: (R)-di-tert-butyl 2-((4-(2-methoxy-2-oxoethyl)benzyl)amino)pentanedionate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; sodium iodide; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 55 ℃; for 15h;

Reference yield: 75.0%

: 92837-84-8
di-tert-butyl (2R)-2-aminopentanedioate

: 106918-32-5
4-carbomethoxyphenylacetaldehyde

: 635309-82-9
(R)-tert-butyl 1-(4-(methoxycarbonyl)-phenethyl)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: di-tert-butyl (2R)-2-aminopentanedioate; 4-carbomethoxyphenylacetaldehyde; With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

In xylene; for 5h; Heating / reflux;