Benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N, 2-dimethyl-N-5-pyrimidinyl-

Base Information

Chemical Name:Benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N, 2-dimethyl-N-5-pyrimidinyl-
CAS No.:928782-98-3
Molecular Formula:C23H17Cl2F3N4O2
Molecular Weight:509.315
Hs Code.:

Synonyms:

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Chemical Property of Benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N, 2-dimethyl-N-5-pyrimidinyl-

Chemical Property:

Purity/Quality:

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Technology Process of Benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N, 2-dimethyl-N-5-pyrimidinyl-

There total 8 articles about Benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N, 2-dimethyl-N-5-pyrimidinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 928782-98-3
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-methyl-N-(5-pyrimidinyl) benzoic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: potassium hydrogencarbonate / tetrahydrofuran / 5 h / Heating / reflux

3.1: sodium acetate / palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 7 h / 110 °C / 11251.1 Torr

3.2: 1.5 h / 80 °C

4.1: ammonia / tetrahydrofuran; water / 18 h / 0 °C

5.1: potassium phosphate; N,N-dimethylethylenediamine / copper(l) iodide / 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

6.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 80 °C

With potassium phosphate; ammonia; sodium acetate; potassium carbonate; potassium hydrogencarbonate; N,N-dimethylethylenediamine; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 928783-00-0
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-(5-pyrimidinyl) benzoic acid amide

: 74-88-4
methyl iodide

: 928782-98-3
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-methyl-N-(5-pyrimidinyl) benzoic acid amide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 1h;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 928782-98-3
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl-N-methyl-N-(5-pyrimidinyl) benzoic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydrogencarbonate / tetrahydrofuran / 5 h / Heating / reflux

2.1: sodium acetate / palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 7 h / 110 °C / 11251.1 Torr

2.2: 1.5 h / 80 °C

3.1: ammonia / tetrahydrofuran; water / 18 h / 0 °C

4.1: potassium phosphate; N,N-dimethylethylenediamine / copper(l) iodide / 1,4-dioxane / 0.33 h / 120 °C / Microwave irradiation

5.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 - 80 °C

With potassium phosphate; ammonia; sodium acetate; potassium carbonate; potassium hydrogencarbonate; N,N-dimethylethylenediamine; palladium diacetate; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;