1,3-Propanediol, 2-(phenylmethoxy)-, monobenzoate, (R)-

Base Information

• Chemical Name: 1,3-Propanediol, 2-(phenylmethoxy)-, monobenzoate, (R)-
• CAS No.: 92917-13-0
• Molecular Formula: C₁₇H₁₈O₄
• Molecular Weight: 286.328
• Mol file: 92917-13-0.mol

Synonyms:

Chemical Property of 1,3-Propanediol, 2-(phenylmethoxy)-, monobenzoate, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Propanediol, 2-(phenylmethoxy)-, monobenzoate, (R)-

There total 5 articles about 1,3-Propanediol, 2-(phenylmethoxy)-, monobenzoate, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-O-benzylglycerol (14690-00-7) + vinyl benzoate (769-78-8,24991-32-0) → (-)-2-(benzyloxy)-3-hydroxypropyl benzoate (109430-97-9) + (+)-2-(benzyloxy)-3-hydroxypropyl benzoate (92917-13-0)

Guidance literature:

With diethylzinc; ((2S,2'S)-((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(pyrrolidine-1,2-diyl))bis(diphenylmethanol); In toluene; at -20 ℃; for 24h; optical yield given as %ee; Inert atmosphere;

DOI:10.1002/chem.200800623

Reference yield:

1,3-di-O-acetyl-2-O-benzylglycerol (105409-38-9) → (+)-2-(benzyloxy)-3-hydroxypropyl benzoate (92917-13-0)

Guidance literature:

Multi-step reaction with 5 steps

1: lipase (E_.⁽¹⁾C₃₁₃₄)

2: 95 percent / p-MeC₆H₄SO₃H / Ambient temperature

3: 95 percent / K₂CO₃ / methanol

4: pyridine

5: p-MeC₆H₄SO₃H / methanol

With potassium carbonate; toluene-4-sulfonic acid; In pyridine; methanol;

DOI:10.1039/c39860001523

Reference yield:

<(R)-2-(benzyloxy)-3-hydroxypropyl> acetate (109429-00-7) → (+)-2-(benzyloxy)-3-hydroxypropyl benzoate (92917-13-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / p-MeC₆H₄SO₃H / Ambient temperature

2: 95 percent / K₂CO₃ / methanol

3: pyridine

4: p-MeC₆H₄SO₃H / methanol

With potassium carbonate; toluene-4-sulfonic acid; In pyridine; methanol;

DOI:10.1039/c39860001523

upstream raw materials:

1,3-di-O-acetyl-2-O-benzylglycerol

<(R)-2-(benzyloxy)-3-hydroxypropyl> acetate

2-O-benzylglycerol

vinyl benzoate

Downstream raw materials:

(R)-1-benzoyloxy-2,3-propanediol