Methyl 2-(2,3-dimethylanilino)benzoate

Base Information

• Chemical Name: Methyl 2-(2,3-dimethylanilino)benzoate
• CAS No.: 1222-42-0
• Molecular Formula: C16H17 N O2
• Molecular Weight: 255.316
• Hs Code.: 2922499990
• DSSTox Substance ID: DTXSID20153542
• Nikkaji Number: J125.892C
• Wikidata: Q83020481
• Mol file: 1222-42-0.mol

Synonyms:1222-42-0;Methyl 2-(2,3-dimethylanilino)benzoate;methyl 2-[(2,3-dimethylphenyl)amino]benzoate;BRN 2218642;Mefenamic Acid Methyl Ester;Benzoic acid, 2-((2,3-dimethylphenyl)amino)-, methyl ester;Benzoic acid, 2-[(2,3-dimethylphenyl)amino]-, methyl ester;Methyl 2-((2,3-dimethylphenyl)amino)benzoate;Monomethyl derivative of Mefenamic acid;2-[(2,3-Dimethylphenyl)amino]benzoic acid methyl ester;Mefenamic acid, methyl ester;Mefenamic acid, methyl deriv.;Mefenamic acid methyl derivative;SCHEMBL11344390;DTXSID20153542;MFCD01661278;AKOS021982822;LS-09746;LS-37239;Methyl 2-(2,3-dimethylanilino)benzoate #;methyl-2-(2,3-dimethylphenylamino)benzoate;methyl2-[(2,3-dimethylphenyl)amino]benzoate;EN300-7388883;2-[(2,3-dimethylphenyl)amino]benzoic acid, methyl ester;2-[(2,3dimethylphenyl)amino]benzoic acid, methyl ester;2-[(2,3-dimethylphenyl) amino]benzoic acid, methyl ester

Chemical Property of Methyl 2-(2,3-dimethylanilino)benzoate

Chemical Property:

• Vapor Pressure: 7.84E-06mmHg at 25°C
• Boiling Point: 375.3°Cat760mmHg
• Flash Point: 180.8°C
• PSA: 38.33000
• Density: 1.13g/cm³
• LogP: 3.90660
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 255.125928785
• Heavy Atom Count: 19
• Complexity: 305

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2-[(2,3-dimethylphenyl)amino]benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)NC2=CC=CC=C2C(=O)OC)C

Technology Process of Methyl 2-(2,3-dimethylanilino)benzoate

There total 3 articles about Methyl 2-(2,3-dimethylanilino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

→ methyl 2-[(2,3-dimethylphenyl)amino]benzoate (1222-42-0)

Guidance literature:

Reference yield: 82.0%

methanol (67-56-1) + mefenamic Acid (61-68-7) → methyl 2-[(2,3-dimethylphenyl)amino]benzoate (1222-42-0)

Guidance literature:

With sulfuric acid; In methanol; Reflux;

DOI:10.1007/s00044-015-1318-8

Reference yield:

mefenamic Acid (61-68-7) + methyl iodide (74-88-4) → methyl 2-[(2,3-dimethylphenyl)amino]benzoate (1222-42-0)

Guidance literature:

mefenamic Acid; With potassium carbonate; In acetone; for 1h;

methyl iodide; In acetone; for 18h; Reflux;

DOI:10.1007/s11164-018-03730-y

upstream raw materials:

methanol

mefenamic Acid

methyl iodide

Downstream raw materials:

2-((2,3-dimethylphenyl)amino)benzohydrazide

Refernces

• 1、 Albayati, Mustafa R.,Kans?z, Sevgi,Dege, Necmi,Kaya, Sava?,Marzouki, Riadh,Lgaz, Hassane,Salghi, Rachid,Ali, Ismat H.,Alghamdi, Majed M.,Chung, Ill-Min. "Synthesis, crystal structure, Hirshfeld surface analysis and DFT calculations of 2-[(2,3-dimethylphenyl)amino]-N’-[(E)-thiophen-2-ylmethylidene]benzohydrazide". . . Retrieved 2020.
• 2、 Aboul-Fadl, Tarek,Abdel-Aziz, Hatem A.,Kadi, Adnan,Bari, Ahmed,Ahmad, Pervez,Al-Samani, Tilal,Ng, Seik Weng. "Microwave-assisted one-step synthesis of fenamic acid hydrazides from the corresponding acids". . p. 3544 - 3551. Retrieved 2011.