6-Dimethylaminopurine

Base Information

• Chemical Name: 6-Dimethylaminopurine
• CAS No.: 938-55-6
• Molecular Formula: C7H9N5
• Molecular Weight: 163.182
• Hs Code.: 29335990
• European Community (EC) Number: 213-344-3
• NSC Number: 401568
• UNII: 649SA4S2CV
• DSSTox Substance ID: DTXSID20239658
• Nikkaji Number: J128.128C
• Wikidata: Q15632695
• Metabolomics Workbench ID: 37267
• ChEMBL ID: CHEMBL407391
• Mol file: 938-55-6.mol

Synonyms:6,6-dimethyladenine;6-(dimethylamino)purine;6-dimethylaminopurine;6-DMAP;adenine, N,N-dimethyl-;adenine, N6,N6-dimethyl-;dimethyladenine;dimethylaminopurine;N(6),N(6)-dimethyladenine;N,N-dimethyladenine;purine, 6-(dimethylamino)-

Chemical Property of 6-Dimethylaminopurine

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.0154mmHg at 25°C
• Melting Point: 259-262 °C(lit.)
• Refractive Index: 1.713
• Boiling Point: 427.4 °C at 760 mmHg
• PKA: 9.38±0.20(Predicted)
• Flash Point: 212.3 °C
• PSA: 57.70000
• Density: 1.365 g/cm³
• LogP: 0.41890
• Storage Temp.: −20°C
• Solubility.: methanol: 0.1 g/mL, clear
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 163.08579531
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

N6- ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 25-27-36/37/38
• Safety Statements: 26-28-36/37/39-45-24/25-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)C1=NC=NC2=C1NC=N2
• Uses: 6-Dimethylaminopurine is a serine threonine protein kinase inhibitor. It inhibits the germinal vesicle breakdown and the meiotic maturation of oocytes. It can be used to rtificially lengthen the pre-maturation period of oocyte growth, in vitro, by inhibiting germinal vesicle breakdown in mouse and human oocytes.

Technology Process of 6-Dimethylaminopurine

There total 20 articles about 6-Dimethylaminopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 6-chloropurine (87-42-3) → 6-Dimethylaminopurine (938-55-6)

Guidance literature:

With potassium carbonate; at 120 ℃; for 10h;

DOI:10.1081/SCC-200026634

Reference yield: 95.0%

N,N-dimethylammonium chloride (506-59-2) + 6-chloropurine (87-42-3) → 6-Dimethylaminopurine (938-55-6)

Guidance literature:

With triethylamine; In butan-1-ol; for 24h; Ambient temperature;

Reference yield: 84.5%

dimethyl amine (124-40-3) + 6-chloropurine (87-42-3) → 6-Dimethylaminopurine (938-55-6)

Guidance literature:

In ethanol; at 110 ℃; for 14h;

DOI:10.1135/cccc20011545

upstream raw materials:

N-(4-amino-6-dimethylamino-pyrimidin-5-yl)-formamide

6-chloro-7H-purine

dimethyl amine

orthoformic acid triethyl ester

Downstream raw materials:

N,N-dimethyl-9-(2,6-dichlorobenzyl)adenine

[3-(2,6-dichlorobenzyl)-3H-purin-6-yl]dimethylamine

N,N-dimethyladenosine

N,N-dimethyl-9-(4-fluorobenzyl)adenine

Refernces

• 1、 Hu, Rong,Wang, Wan-Li,Xiao, Kun-Jie,Wang, Ning-Yu. "9-Sulfonyl-9(H)-Purine Derivatives Inhibit HCV Replication Via their Degradation Species". . p. 36 - 45. Retrieved 2021/04/19.
• 2、 Alves, M. Jose,Carvalho, M. Alice,Carvalho, Silvia,Dias, Alice M.,Fernandes, Francisco H.,Proenca, M. Fernanda. "A new approach to the synthesis of N,N-dialkyladenine derivatives". . p. 4881 - 4887. Retrieved 2008/03/14.