10-Oxa-2,5,8-triazadodecanoic acid, 5-[[4-(hydroxymethyl)phenoxy]carbonyl]-11,11-dimethyl-9-oxo-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 10-Oxa-2,5,8-triazadodecanoic acid, 5-[[4-(hydroxymethyl)phenoxy]carbonyl]-11,11-dimethyl-9-oxo-, 1,1-dimethylethyl ester
• CAS No.: 929535-87-5
• Molecular Formula: C22H35N3O7
• Molecular Weight: 453.536
• Mol file: 929535-87-5.mol

Synonyms:

Chemical Property of 10-Oxa-2,5,8-triazadodecanoic acid, 5-[[4-(hydroxymethyl)phenoxy]carbonyl]-11,11-dimethyl-9-oxo-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-Oxa-2,5,8-triazadodecanoic acid, 5-[[4-(hydroxymethyl)phenoxy]carbonyl]-11,11-dimethyl-9-oxo-, 1,1-dimethylethyl ester

There total 1 articles about 10-Oxa-2,5,8-triazadodecanoic acid, 5-[[4-(hydroxymethyl)phenoxy]carbonyl]-11,11-dimethyl-9-oxo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

bis(2-tert-butyloxycarbonylaminoethyl)amine (117499-16-8) + carbonic acid 4-hydroxymethylphenyl ester 4-nitrophenyl ester (334999-60-9) → {2-[(2-tert-butoxycarbonylamino-ethyl)-(4-hydroxymethyl-phenoxycarbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester (929535-87-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1002/chem.200601263

Reference yield: 60.0%

{2-[(2-tert-butoxycarbonylamino-ethyl)-(4-hydroxymethyl-phenoxycarbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester (929535-87-5) + 4-Nitrophenyl chloroformate (7693-46-1) → carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester (929535-88-6)

Guidance literature:

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1002/chem.200601263

Reference yield:

{2-[(2-tert-butoxycarbonylamino-ethyl)-(4-hydroxymethyl-phenoxycarbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester (929535-87-5) → methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester (929535-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / N,N-diisopropyl ethylamine; pyridine / tetrahydrofuran / 1 h / 20 °C

2: 131 mg / NEt₃ / dimethylformamide

With pyridine; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/chem.200601263

upstream raw materials:

bis(2-tert-butyloxycarbonylaminoethyl)amine

carbonic acid 4-hydroxymethylphenyl ester 4-nitrophenyl ester

Downstream raw materials:

carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester

methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester