117499-16-8Relevant academic research and scientific papers
Optimizing saccharide-directed molecular delivery to biological receptors: Design, synthesis, and biological evaluation of glycodendrimer-cyclodextrin conjugates
Benito, Juan M.,Gomez-Garcia, Marta,Ortiz Mellet, Carmen,Baussanne, Isabelle,Defaye, Jacques,Garcia Fernandez, Jose M.
, p. 10355 - 10363 (2004)
Dendritic β-cyclodextrin (βCD) derivatives bearing multivalent mannosyl ligands have been prepared and assessed for their binding efficiency toward the tetrameric plant lectin concanavalin A (Con A) and a mammalian mannose/fucose specific cell surface receptor from macrophages. The synthetic strategy exploits the reactivity between isothiocyanate and amine functionalities for the high-yielding assembly via thioureido links of the various building blocks, including host, spacer, branching, and carbohydrate ligand elements. The methodology has been applied to the preparation of a series of βCD-polymannoside scaffolds differing in the ligand valency and geometry. This series allowed us to explore: (i) The effects of the glycodendritic architecture on the binding efficiency; (ii) the mutual influence between the cyclodextrin core and the glycodendritic moieties on the molecular inclusion and lectin-binding properties; and (iii) the consequence of inclusion complex formation, using the anticancer drug docetaxel (Taxotere) as a target guest, on biological recognition. Our results confirm the high drug solubilization capability of this new type of βCD-dendrimer construct and indicate that subtle changes in the architecture of the conjugate may have important consequences on receptor affinity. Interestingly, the host-guest interaction can be monitored to build up supramolecular dynamic glycoclusters with increased lectin affinity. Alternatively, the information obtained from the structure-lectin-binding avidity-inclusion capability studies has been put forward in the design of very efficient molecular transporters for docetaxel based on glycodendritic CD dimers.
Synthesis, in vitro, and in silico evaluation of organometallic technetium and rhenium thymidine complexes with retained substrate activity toward human thymidine kinase type 1
Desbouis, Dominique,Struthers, Harriet,Spiwok, Vojtech,Küster, Tatjana,Schibli, Roger
, p. 6689 - 6698 (2008)
Human cytosolic thymidine kinase (hTK1) has proven to be a suitable target for noninvasive imaging of cancer cell proliferation using radiolabeled substrates such as [18F]fluorothymidine ([18F]FLT). However, a thymidine tracer useful for single photon emission tomography (SPECT) based on the inexpensive radionuclide technetium-99m would be of significant interest. In this work, a series of thymidine derivatives labeled with the organometallic [M(CO)3]+ core (M = 99mTc, Re) were synthesized. Neutral, cationic, and anionic complexes were readily formed in aqueous media, and all were substrates of recombinant hTK1 when incubated with ATP. The neutral complexes were phosphorylated to a greater extent than the charged complexes. The extent of phosphorylation was further improved by increasing the spacer length separating thymidine and the organometallic core. A molecular dynamics simulation study performed with a modified hTK1 structure supported the experimental findings. In vitro cell internalization experiments performed in a human neuroblastoma cell line (SKNMC) showed low uptake of the charged complexes but significant uptake for the neutral, lipophilic complexes with a log P value >1.
Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase
Lukesh, John C.,Andersen, Kristen A.,Wallin, Kelly K.,Raines, Ronald T.
, p. 8598 - 8602 (2014)
Organocatalysts derived from diethylenetriamine effect the rapid isomerization of non-native protein disulfide bonds to native ones. These catalysts contain a pendant hydrophobic moiety to encourage interaction with the non-native state, and two thiol gro
Selective turn-on sensing of Cu2+ and Cl? by a ferrocene-modified pyrene derivative
Tong, Ling,Sun, Shuhua,Qiao, Min,Fan, Junmei,Ding, Liping
, p. 131 - 137 (2019)
Detection of metal ions and anions by fluorescent turn-on sensors are attractive and challenging. In this work, we designed and synthesized a ferrocene-modified bispyrene derivative, DPFc, as a fluorescent turn-on sensor to detect both Cu2+ and Cl?. The probe has good fluorescence stability in acetonitrile and can form an intramolecular excimer. When Cl? is present in the system, the addition of Cu2+ could effectively enhance the fluorescence of the probe, and the turn-on response to Cu2+ is selective by comparison with other metal ions. The probe also shows selective responses to Cl? over other type anions when an inert copper salt is present. The fluorescent turn-on responses to Cu2+ is attributed to the oxidation of Fe(II) in the ferrocene unit into Fe(III) by Cu2+ that prohibits the electron transfer-induced fluorescence quenching. UV–vis absorption measurements revealed that the presence of Cl? helped to bind with the probe and realized the oxidation of ferrocene unit by Cu2+. The present sensor could be used as a selective turn-on sensor for both Cu2+ and Cl?.
Selective convergent synthesis of aliphatic polyurethane dendrimers
Feast, W. James,Rannard, Steve P.,Stoddart, Alison
, p. 9704 - 9706 (2003)
An overview is given of the first convergent synthesis of aliphatic polyurethane homodendrimers. The synthesis only uses urethane links and has a repeating structure that is consistent from the surface groups through to the core nitrogen atom. Dendrimer molecules up to the third generation and dendrons up to the fourth generation have been synthesized with masses over 7000 Da.
Covalent capture of self-assembled rosette nanotubes
Deng, Bo-Liang,Beingessner, Rachel L.,Johnson, Ross S.,Girdhar, Navdeep K.,Danumah, Christophe,Yamazaki, Takeshi,Fenniri, Hicham
, p. 7157 - 7162 (2012)
Rosette nanotubes (RNTs) are self-assembled tubular architectures which have extensive chemical and physical tuning capabilities, owing to their ease of surface functionalization and flexible inner channel design. To marry these tunable features of the RN
A ternary sensor system based on pyrene derivative-SDS assemblies-Cu2+ displaying dual responsive signals for fast detection of arginine and lysine in aqueous solution
Cao, Jianhua,Ding, Liping,Zhang, Yuanyuan,Wang, Shihuai,Fang, Yu
, p. 66 - 74 (2016)
A new cationic pyrene derivative-based fluorescent probe (IPy) was designed and synthesized. This cationic fluorophore with two imidazolium groups can be well-dissolved in aqueous solution and exhibits only monomer emission. The anionic surfactant SDS ass
An efficient chelator for complexation of thorium-227
Ramdahl, Thomas,Bonge-Hansen, Hanne T.,Ryan, Olav B.,Larsen, ?smund,Herstad, Gunnar,Sandberg, Marcel,Bjerke, Roger M.,Grant, Derek,Brevik, Ellen M.,Cuthbertson, Alan S.
, p. 4318 - 4321 (2016)
We present the synthesis and characterization of a highly efficient thorium chelator, derived from the octadentate hydroxypyridinone class of compounds. The chelator forms extremely stable complexes with fast formation rates in the presence of Th-227 (ambient temperature, 20?min). In addition, mouse biodistribution data are provided which indicate rapid hepatobiliary excretion route of the chelator which, together with low bone uptake, supports the stability of the complex in vivo. The carboxylic acid group may be readily activated for conjugation through the ?-amino groups of lysine residues in biomolecules such as antibodies. This chelator is a critical component of a new class of Targeted Thorium Conjugates (TTCs) currently under development in the field of oncology.
Polyamine-substituted gadolinium chelates: A new class of intracellular contrast agents for magnetic resonance imaging of tumors
Wolf, Markus,Hull, William E.,Mier, Walter,Heiland, Sabine,Bauder-Wüst, Ulrike,Kinscherf, Ralf,Haberkorn, Uwe,Eisenhut, Michael
, p. 139 - 148 (2007)
A new class of intracellular contrast agents (CA) for magnetic resonance imaging has been developed, based on Gd(DTPA) with two positively charged amide-linked substituents. Uptake of Gd(DTPA) into cultured tumor cell lines (B16 mouse melanoma, MH3924A Morris hepatoma) was below the detection limit while CA with the melanin-binding pharmacophore 2-(diethylamino)ethylamine reached intracellular concentrations of ca. 0.03 fmol/cell (ca. 20 μM) for melanoma and 0.02 fmol/cell for hepatoma (24 h at 10 μM CA). With the polyamine substituents bis(2-aminoethyl)amine or spermidine, CA uptake increased up to 3-fold for melanoma (0.083 fmol/cell) and 9-fold for hepatoma (0.18 fmol/cell). Uptake of polyamine-substituted CA was reduced by the polyamine transport inhibitor benzyl viologen. Molar relaxivities for three Gd-DTPA-polyamine complexes were in the range 5.6-6.9 for the free complex in solution and 7.7-23.5 s-1 mM-1 for Morris hepatoma cell pellets. T1-weighted magnetic resonance imaging at 2.35 T of rats with MH3924A tumors showed contrast enhancement in tumor at 1 and 24 h postinjection of polyamine-substituted CA.
Chemical, radiochemical and biological studies of new gallium(iii) complexes with hexadentate chelators
Silva, Francisco,Campello, Maria Paula C.,Gano, Lurdes,Fernandes, Clia,Santos, Isabel,Santos, Isabel C.,Ascenso, Jos R.,Joo Ferreira,Paulo, Antnio
, p. 3342 - 3355 (2015)
New N4O2-donor acyclic chelators 2-[[2-[2-(3,5-dimethylpyrazol-1-yl)ethyl-[2-[(2-hydroxyphenyl)methylamino]ethyl]amino]ethylamino]methyl]phenol (H2Lpz,NH) and 2-[[2-[2-[(2-hydroxyphenyl)methylamino]ethyl-(2-pyri
