4-(4-Methoxyphenyl)-5-phenylfuran-2(5H)-one

Base Information

• Chemical Name: 4-(4-Methoxyphenyl)-5-phenylfuran-2(5H)-one
• CAS No.: 93098-01-2
• Molecular Formula: C17H14O3
• Molecular Weight: 266.296
• DSSTox Substance ID: DTXSID00540936
• Mol file: 93098-01-2.mol

Synonyms:93098-01-2;4-(4-Methoxyphenyl)-5-phenylfuran-2(5H)-one;DTXSID00540936

Chemical Property of 4-(4-Methoxyphenyl)-5-phenylfuran-2(5H)-one

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 266.094294304
• Heavy Atom Count: 20
• Complexity: 374

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CC(=O)OC2C3=CC=CC=C3

Technology Process of 4-(4-Methoxyphenyl)-5-phenylfuran-2(5H)-one

There total 2 articles about 4-(4-Methoxyphenyl)-5-phenylfuran-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-acetoxy-1-(4-methoxyphenyl)-2-phenylethanone (108791-38-4) + ethyl bromoacetate (105-36-2) → β-(4-methoxyphenyl)-γ-phenyl-Δα,β-butenolide (93098-01-2)

Guidance literature:

With zinc; In benzene; for 3h; Heating;

Reference yield:

ethyl 4-hydroxy-4-phenylbut-2-ynoate (72036-37-4) + 4-methoxyphenylboronic acid (5720-07-0) → 3-(4-methoxyphenyl)-5-phenyl-2(5H)-furanone (97861-42-2) + β-(4-methoxyphenyl)-γ-phenyl-Δα,β-butenolide (93098-01-2)

Guidance literature:

With 1,2-bis-(diphenylphosphino)ethane; palladium diacetate; In chloroform; at 60 ℃; for 12h;

DOI:10.1016/j.tetlet.2004.07.129

Reference yield: 36.0%

β-(4-methoxyphenyl)-γ-phenyl-Δα,β-butenolide (93098-01-2) → 4-(4-Hydroxy-phenyl)-5-phenyl-5H-furan-2-one (132590-03-5)

Guidance literature:

With pyridine hydrochloride; at 180 - 200 ℃; for 1h;

upstream raw materials:

2-acetoxy-1-(4-methoxyphenyl)-2-phenylethanone

ethyl bromoacetate

ethyl 4-hydroxy-4-phenylbut-2-ynoate

4-methoxyphenylboronic acid

Downstream raw materials:

4-(4-Hydroxy-phenyl)-5-phenyl-5H-furan-2-one

4-(2-Phenyl-furan-3-yl)-phenol

1-{2-[4-(2-Phenyl-furan-3-yl)-phenoxy]-ethyl}-pyrrolidine

1-{2-[4-(2-Phenyl-furan-3-yl)-phenoxy]-ethyl}-piperidine