4-[(4-Methylphenyl)sulphonyl]morpholine

Base Information

• Chemical Name: 4-[(4-Methylphenyl)sulphonyl]morpholine
• CAS No.: 6339-26-0
• Molecular Formula: C11H15 N O3 S
• Molecular Weight: 241.311
• Hs Code.: 2934999090
• European Community (EC) Number: 228-731-2
• NSC Number: 12118
• UNII: PYW39YE2V4
• DSSTox Substance ID: DTXSID10212793
• Nikkaji Number: J123.432C
• Wikidata: Q83087995
• Mol file: 6339-26-0.mol

Synonyms:4-tosylmorpholine;6339-26-0;4-(4-methylphenyl)sulfonylmorpholine;4-[(4-METHYLPHENYL)SULPHONYL]MORPHOLINE;4-(Toluene-4-sulfonyl)-morpholine;4-(p-Tolylsulfonyl)morpholine;4-[(4-Methylphenyl)sulfonyl]morpholine;Morpholine, 4-(p-tolylsulfonyl)-;N-(p-Toluenesulfonyl)morpholine;Morpholine, 4-((4-methylphenyl)sulfonyl)-;Morpholine, 4-[(4-methylphenyl)sulfonyl]-;EINECS 228-731-2;BRN 0210845;PYW39YE2V4;AI3-30824;NSC-12118;4-(4-methylbenzenesulfonyl)morpholine;4-((4-Methylphenyl)sulphonyl)morpholine;4-[(4-Methylbenzene)sulfonyl]morpholine;4-27-00-00616 (Beilstein Handbook Reference);C11H15NO3S;4-((4-Methylphenyl)sulfonyl)morpholine;tosylmorpholine;NSC12118;UNII-PYW39YE2V4;Oprea1_144727;Oprea1_757999;CBDivE_003744;SCHEMBL171151;4-(p-Tolylsulphonyl)morpholine;DTXSID10212793;HMS1607K16;MFCD00196072;NSC 12118;STL089650;AKOS001586388;AM87110;NCGC00181906-01;AS-64189;LS-93468;4-[(4-Methylphenyl)sulfonyl]morpholine #;CS-0036083;Morpholine, 4-((4-methylphenyl)sulphonyl)-;W11725;AE-848/00888033;Z45515795

Chemical Property of 4-[(4-Methylphenyl)sulphonyl]morpholine

Chemical Property:

• Vapor Pressure: 3.85E-06mmHg at 25°C
• Boiling Point: 385.3°C at 760 mmHg
• Flash Point: 186.8°C
• PSA: 54.99000
• Density: 1.256g/cm³
• LogP: 2.03460
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 241.07726451
• Heavy Atom Count: 16
• Complexity: 309

Purity/Quality:

99% ^*data from raw suppliers

4-Tosylmorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)N2CCOCC2

Technology Process of 4-[(4-Methylphenyl)sulphonyl]morpholine

There total 61 articles about 4-[(4-Methylphenyl)sulphonyl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(trimethylsilyl)morpholine (13368-42-8) + p-toluenesulfonyl chloride (98-59-9) → 4-tosylmorpholine (6339-26-0)

Guidance literature:

In acetonitrile; for 1h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.08.034

Reference yield: 99.0%

2,2'-diiodoethyl ether (34270-90-1) + sodium p-toluenesulfonamide (18522-92-4) → 4-tosylmorpholine (6339-26-0)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 5h;

DOI:10.1021/jo00250a020

Reference yield: 99.0%

4-(benzoyloxy)morpholine (5765-65-1) + sodium 4-methylbenzenesulfinate (824-79-3) → 4-tosylmorpholine (6339-26-0)

Guidance literature:

4-(benzoyloxy)morpholine; sodium 4-methylbenzenesulfinate; In 1,2-dichloro-ethane; at 30 ℃; for 12h; Schlenk technique; Inert atmosphere;

With copper(ll) bromide; In 1,2-dichloro-ethane; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c5cc06069a

upstream raw materials:

2,2'-diiodoethyl ether

toluene-4-sulfonamide

morpholine

p-toluene sulfinic acid

Downstream raw materials:

morpholine

diethyl (5-methyl-2-(morpholinosulfonyl) phenyl)phosphonate

morpholin hydrochloride

C₂₈H₂₄BrN₃O₁₀S₂

Refernces

• 1、 Chen, Rongxiang,Xu, Shaohong,Shen, Fumin,Xu, Canran,Wang, Kaikai,Wang, Zhanyong,Liu, Lantao. "Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides". . . Retrieved 2021/09/20.
• 2、 Wang, Xuefeng,Yang, Min,Ye, Shengqing,Kuang, Yunyan,Wu, Jie. "S(vi) in three-component sulfonamide synthesis: Use of sulfuric chloride as a linchpin in palladium-catalyzed Suzuki-Miyaura coupling". . p. 6437 - 6441. Retrieved 2021/05/19.