2-Bromo-1-[2-methoxy-4-(methylthio)phenyl]ethanone

Base Information

Chemical Name:2-Bromo-1-[2-methoxy-4-(methylthio)phenyl]ethanone
CAS No.:93276-66-5
Molecular Formula:C10H11BrO2S
Molecular Weight:275.166
Hs Code.:
DSSTox Substance ID:DTXSID401228615

Synonyms:93276-66-5;SCHEMBL7293033;DTXSID401228615;2-Bromo-1-[2-methoxy-4-(methylthio)phenyl]ethanone

Suppliers and Price of 2-Bromo-1-[2-methoxy-4-(methylthio)phenyl]ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Bromo-1-[2-methoxy-4-(methylthio)phenyl]ethanone

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:273.96631
Heavy Atom Count:14
Complexity:199

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)SC)C(=O)CBr

Technology Process of 2-Bromo-1-[2-methoxy-4-(methylthio)phenyl]ethanone

There total 9 articles about 2-Bromo-1-[2-methoxy-4-(methylthio)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 114552-63-5
2-methoxy-4-(methylthio)-α-(trimethylsilyl)acetophenone

: 93276-66-5
α-bromo-2'-methoxy-4'-methylthioacetophenone

Guidance literature:: With N-Bromosuccinimide; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1021/jm00403a018

Reference yield: 65.0%

: 93276-65-4
2'-methoxy-4'-methylthioacetophenone

: 93276-66-5
α-bromo-2'-methoxy-4'-methylthioacetophenone

Guidance literature:: With copper(ll) bromide; In chloroform; ethyl acetate; for 3h; Heating;
DOI:10.1016/0223-5234(92)90004-K

Reference yield:

: 372-20-3
3-fluorophenol

: 93276-66-5
α-bromo-2'-methoxy-4'-methylthioacetophenone

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / CH₂Cl₂ / 1 h / 0 °C

2: 75 percent / aluminium chloride / 160 - 180 °C

3: 92 percent / sodium hydride / dimethylformamide / 1 h / 0 °C

4: 55 percent / potassium hydroxide / dimethylformamide / 2 h / 0 °C

5: 44 g / diisopropylamine, n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) room temperature, 1.5 h

6: 70 percent / N-bromosuccinimide / tetrahydrofuran / 0.5 h / -78 °C

With pyridine; potassium hydroxide; N-Bromosuccinimide; n-butyllithium; aluminium trichloride; sodium hydride; diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00403a018