Technology Process of Benzoic acid, 2-(3-methyl-1-oxo-2(1H)-isoquinolinyl)-, methyl ester
There total 5 articles about Benzoic acid, 2-(3-methyl-1-oxo-2(1H)-isoquinolinyl)-, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 2-isocyanatobenzoate; 7-methylbicyclo[4.2.0]octa-1,3,5-trien-7-ol;
With
[Rh(OH)(cod)]2;
In
1,2-dichloro-ethane;
at 50 ℃;
for 5h;
Sealed tube;
Schlenk technique;
Inert atmosphere;
With
trifluoroacetic acid;
In
1,2-dichloro-ethane;
at 20 ℃;
for 0.5h;
regioselective reaction;
Sealed tube;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/acs.orglett.8b03653
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 33.3 percent / tert-BuOK / tetrahydrofuran / 0.5 h / Ambient temperature
2: 0.07 g / HCl / 20 h / Heating
With
hydrogenchloride; potassium tert-butylate;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 67.3 percent / SOCl2 / 1 h / Ambient temperature
2: 33.3 percent / tert-BuOK / tetrahydrofuran / 0.5 h / Ambient temperature
3: 0.07 g / HCl / 20 h / Heating
With
hydrogenchloride; thionyl chloride; potassium tert-butylate;
In
tetrahydrofuran;
