2852-91-7

Usage

Uses

Used in Pharmaceutical Industry:
(2-CARBOXYPHENYL)ACETONE is used as an intermediate for the synthesis of various drugs, contributing to the development of new medications and therapies.
Used in Organic Compound Production:
(2-CARBOXYPHENYL)ACETONE is used as a precursor for the production of other organic compounds, such as dyes and fragrances, enhancing the range of products available in these industries.
Used in Synthesis of Complex Organic Molecules:
(2-CARBOXYPHENYL)ACETONE is used as a versatile reagent in the synthesis of complex organic molecules, enabling the creation of intricate chemical structures for various applications.
Safety Precautions:
It is important to handle (2-CARBOXYPHENYL)ACETONE with care, as it may be harmful if swallowed, inhaled, or in contact with skin and eyes. Proper safety measures should be taken during its use and storage to minimize potential risks.

InChI:InChI=1/C10H10O3/c1-7(11)6-8-4-2-3-5-9(8)10(12)13/h2-5H,6H2,1H3,(H,12,13)

Upstream product

• 29539-21-7 3-methylisocoumarin 
• 17496-14-9 2,3-dihydro-2-methyl-1H-inden-1-one 
• 52962-26-2 3-(o-carboxyphenyl)pentane-2,4-dione 
• 75724-96-8 3-(chloroacetyl)phthalide 
• 115912-93-1 2-(2-nitropropyl)benzoic acid 
• 67-64-1 acetone 
• 88-65-3 2-bromobenzoic-acid 
• 1315259-65-4 1,4-epoxy-4-methyl-1H,4H-2,3-benzodioxepin 
• 708-14-5 phthalide-3-carboxylic acid 
• 129881-51-2 acid chloride of 1-oxo-1,3-dihydroisobenzofuran-3-carboxylic acid 
• 528-46-1 phthalonic acid 
• 79017-08-6 3-(1-nitroethyl)-1(3H)-isobenzofuranone 
• 16859-59-9 3-hydroxy-1(3H)-isobenzofuranone 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 73013-47-5 2-(2-Oxo-propyl)-benzoic acid ethyl ester 
• 7115-18-6 methyl 2-(2-oxopropyl)benzoate 
• 7114-80-9 3-methylisoquinolin-1-ol 
• 1259022-97-3 (E)-2-[4-(3,4-dimethoxyphenyl)-2-oxobut-3-enyl]benzoic acid 
• 185738-14-1 2-(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1 H-indol-3-yl) benzoic acid 
• 862311-07-7 2-(4-methoxyphenyl)-3-methylisoquinolin-1(2H)-one 
• 7114-80-9 3-methylisoquinolone 
• 93361-25-2 methyl 2-(3-methyl-1-oxoisoquinolin-2(1H)-yl)benzoate 
• 93361-26-3 2-(2-carbamoylphenyl)-3-methylisocarbostyril 
• 93361-24-1 2-(3-methyl-1-oxoisoquinolin-2(1H)-yl)benzonitrile 

Relevant academic research and scientific papers

Synthesis and X-ray crystal structure analysis of 1,4-epoxy-4-methyl-1H,4H- 2,3-benzodioxepin

Ozonolysis of 2-methyl-1H-indene (1) afforded the stable secondary ozonide 1,4-epoxy-4-methyl-1H,4H-2,3-benzodioxepin (2). This compound crystallizes in two polymorphic forms, depending on the solvent used. The monoclinic form 2a containing two symmetry-independent molecules (enantiomers) is obtained by crystallization from dichloromethane. In contrast, the orthorhombic modification 2b is obtained from ethyl acetate solution and crystallizes as a conglomerate of enantiomerically pure single crystals. Additionally, the ring-opened product 2-(2-oxopropyl)benzoic acid (3) was obtained and investigated by X-ray crystal structure analysis.

Comparison of analgesic effects of isosteric variations of salicylic acid and aspirin (Acetylsalicylic acid)

A reliable and sensitive method was used to compare the analgesic activities of salicylic acid and aspirin (acetylsalicylic acid) and several phenoxy substituted isosteric pairs. Those isosteric compounds studied did not show analgesic activity. The analgesic activity of aspirin was more than twofold greater than that of salicylic acid.

Selective C-C Bond Cleavage of Cycloalkanones by NaNO2/HCl

A novel selective fragmentation of cycloalkanones by NaNO2/HCl has been established. The C-C bond cleavage reaction proceeds smoothly under mild conditions, selectively affording versatile keto acids or oxime acids. The methodology can streamline the synthesis of valuable chiral molecules and isocoumarins from readily available feedstocks.

Fused ring 4-oxopyrimidine derivative

The present invention provides a compound represented by formula (I) below, or a pharmaceutically acceptable salt thereof, which, having histamine H3 receptor antagonist or inverse agonist activity, is useful in the prophylaxis or therapy of metabolic diseases, circulatory diseases, or nervous system diseases. [where, for example, Ar is a divalent group formed by eliminating two hydrogen atoms from benzene, X1 is a nitrogen atom, sulfur atom or oxygen atom, R1 is a 5- to 6-membered heteroaryl group, Ring A is a 5- to 6-membered heteroaryl ring, R2 and R3 are amino groups or alkylamino groups, and X2 is represented by formula (II): (where R4 and R5 are lower alkyl groups, and n is an integer from 2 to 4).]

Aqueous organotin chemistry: Part 3 - Triphenyltin hydride and di-n-butyltin dichloride mediated nucleophilic substitution of 2-iodobenzoates in water

This paper demonstrates the nucleophilic displacement of the iodine in 2-iodobenzoates mediated by triphenyltin hydride and di-n-butyltin dichloride in water.

Reactions of carbonyl compounds in basic solutions. Part 21. The mechanisms of the alkaline hydrolysis of substituted methyl 2-(2-oxopropyl)- and 2-(2-oxo-2-phenylethyl)-benzoates and 2-(2-acetylphenyl)- and 2-(2-benzoylphenyl)-acetates

Rate coefficients have been measured for the alkaline hydrolysis of methyl 2-[2-oxo-2-(3- or 4-substituted phenyl)ethyl]benzoates, 2-[2-(3- or 4-substituted benzoyl)phenyl]acetates,2-(2-oxopropyl) and 2-(1,1-dimethyl-2- oxopropyl)benzoates, 2-(2-acetylphenyl)acetate and 2-(2-acetylphenyl)-2,2- dimethylacetates in 70% (v/v) dioxane-water at 30.0 °C. Those for the six parent esters were also measured at 45.0 and 60.0 °C and the enthalpies and entropies of activation have been evaluated. The relative rates of hydrolysis, activation parameters and substituent effects have been used to demonstrate neighbouring participation by the keto-carbonyl groups in the alkaline hydrolysis of the esters under study. For comparable systems, participation by six-membered ring intermediates appears somewhat less advantageous than five-membered.

A New Procedure for Regiospecific Syntheses of Benzopyran-1-ones

A new, general route to benzopyran-1-ones 33 from phthalaldehydic acids 27 and nitroalkanes 28 is described.The sequence permits strightforward variation of both the 3-substituent and the pattern of functionalization on the aromatic ring of the benzopyran

Aspects of Tautomerism: Part X - Neighbouring Group Effects on the Structure and Reactivity Patterns of Acid Chlorides

The influence of neighbouring groups on the structure and reactivity patterns of over one hundred acid chlorides derived from γ- and δ-keto acids, 1,2- and 1,3-dicarboxylic acid half-esters and diacid chlorides have been examined.Contrary to reports in the literature, text books and monographs, evidence has been obtained for the non-existence of tautomerism between the isomeric pairs of either acid chlorides or half-ester acid chlorides.ce.