Syncarpic acidSee

Base Information

• Chemical Name: Syncarpic acidSee
• CAS No.: 77744-52-6
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.219
• Mol file: 77744-52-6.mol

Synonyms:

Chemical Property of Syncarpic acidSee

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Syncarpic acidSee

There total 4 articles about Syncarpic acidSee which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-acetyl-5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione (7073-22-5) → 5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione (77744-52-6)

Guidance literature:

With hydrogenchloride; In water; for 4h; Reflux;

DOI:10.1002/anie.200903906

Reference yield: 67.0%

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) + methyl iodide (74-88-4) → 5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione (77744-52-6)

Guidance literature:

2,4,6-trihydroxyacetophenone; methyl iodide; With sodium methylate;

With hydrogenchloride; In water; Reflux;

DOI:10.1039/c6ra08776k

Reference yield: 56.0%

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) + sodium methylate (124-41-4) + methyl iodide (74-88-4) → 5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione (77744-52-6)

Guidance literature:

2,4,6-trihydroxyacetophenone; sodium methylate; methyl iodide; With boron trifluoride diethyl etherate; In methanol; at 20 ℃; for 24h;

With hydrogenchloride; for 24h; Reflux;

DOI:10.1016/j.tet.2022.132631

upstream raw materials:

4-acetyl-5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione

2,4,6-trihydroxyacetophenone

methyl iodide

sodium methylate

Downstream raw materials:

5-hydroxy-2,2,6,6-tetramethyl-4-(2-methyl-1-(2,4,6-trihydroxy-3-(1-(2-hydroxy-3,3,5,5-tetramethyl-4,6-dioxocyclohex-1-enyl)-2-methylpropyl)-5-isobutyrylphenyl)propyl)cyclohex-4-ene-1,3-dione

5-hydroxy-2,2,6,6-tetramethyl-4-(3-methyl-1-(2,4,6-trihydroxy-3-isobutyrylphenyl)butyl)cyclohex-4-ene-1,3-dione

2,2,4,4-tetramethyl-6-(2-methylpropylidene)-cyclohexane-1,3,5-trione

Refernces

• 1、 Liu, Hong-Xin,Chen, Kai,Yuan, Yao,Xu, Zhi-Fang,Tan, Hai-Bo,Qiu, Sheng-Xiang. "Rhodomentones A and B, novel meroterpenoids with unique NMR characteristics from: Rhodomyrtus tomentosa". . p. 7354 - 7360. Retrieved 2016.
• 2、 Oka, Sousuke,Hashimoto, Shintaro,Hisano, Kazuki,Nishino, Hiroshi. "Mn(III)-catalyzed aerobic oxidation of 2-alkenyl-1,3-diketone enols. Synthesis of 1,2-dioxin-3-ols and natural phytohormone G factors". supporting information. . Retrieved 2022/01/23.
• 3、 -. "Peachy ketones and their application in the preparation of anti-flu virus drugs". Paragraph 0049-0052; 0057-0058. . Retrieved 2021/12/07.