4,4'-[[2,4,6-Trihydroxy-5-(2-methyl-1-oxopropyl)-1,3-phenylene]bis(2-methylpropane-1,1-diyl)]bis[5-hydroxy-2,2,6,6-tetramethyl-4-cyclohexene-1,3-dione]

Base Information

• Chemical Name: 4,4'-[[2,4,6-Trihydroxy-5-(2-methyl-1-oxopropyl)-1,3-phenylene]bis(2-methylpropane-1,1-diyl)]bis[5-hydroxy-2,2,6,6-tetramethyl-4-cyclohexene-1,3-dione]
• CAS No.: 54247-21-1
• Molecular Formula: C38H52 O10
• Molecular Weight: 668.825
• Mol file: 54247-21-1.mol

Synonyms:Myrtucommulone;Myrtucommulone A

Chemical Property of 4,4'-[[2,4,6-Trihydroxy-5-(2-methyl-1-oxopropyl)-1,3-phenylene]bis(2-methylpropane-1,1-diyl)]bis[5-hydroxy-2,2,6,6-tetramethyl-4-cyclohexene-1,3-dione]

Chemical Property:

• PSA: 186.50000
• LogP: 7.15390

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4'-[[2,4,6-Trihydroxy-5-(2-methyl-1-oxopropyl)-1,3-phenylene]bis(2-methylpropane-1,1-diyl)]bis[5-hydroxy-2,2,6,6-tetramethyl-4-cyclohexene-1,3-dione]

There total 6 articles about 4,4'-[[2,4,6-Trihydroxy-5-(2-methyl-1-oxopropyl)-1,3-phenylene]bis(2-methylpropane-1,1-diyl)]bis[5-hydroxy-2,2,6,6-tetramethyl-4-cyclohexene-1,3-dione] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phlorisobutyrophenone (35458-21-0) + 2,2,4,4-tetramethyl-6-(2-methylpropylidene)-cyclohexane-1,3,5-trione (61565-12-6) → 5-hydroxy-2,2,6,6-tetramethyl-4-(2-methyl-1-(2,4,6-trihydroxy-3-(1-(2-hydroxy-3,3,5,5-tetramethyl-4,6-dioxocyclohex-1-enyl)-2-methylpropyl)-5-isobutyrylphenyl)propyl)cyclohex-4-ene-1,3-dione (54247-21-1)

Guidance literature:

phlorisobutyrophenone; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

2,2,4,4-tetramethyl-6-(2-methylpropylidene)-cyclohexane-1,3,5-trione; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.200903906

Reference yield: 66.0%

syncarpic acid (7181-79-5) + phlorisobutyrophenone (35458-21-0) + isobutyraldehyde (78-84-2) → 5-hydroxy-2,2,6,6-tetramethyl-4-(2-methyl-1-(2,4,6-trihydroxy-3-(1-(2-hydroxy-3,3,5,5-tetramethyl-4,6-dioxocyclohex-1-enyl)-2-methylpropyl)-5-isobutyrylphenyl)propyl)cyclohex-4-ene-1,3-dione (54247-21-1)

Guidance literature:

With L-proline; In ethanol; at 20 ℃; for 24h; Reagent/catalyst; Green chemistry;

DOI:10.1016/j.tet.2017.10.011

Reference yield: 35.0%

phlorisobutyrophenone (35458-21-0) + 5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione (77744-52-6) + isobutyraldehyde (78-84-2) → 5-hydroxy-2,2,6,6-tetramethyl-4-(2-methyl-1-(2,4,6-trihydroxy-3-(1-(2-hydroxy-3,3,5,5-tetramethyl-4,6-dioxocyclohex-1-enyl)-2-methylpropyl)-5-isobutyrylphenyl)propyl)cyclohex-4-ene-1,3-dione (54247-21-1)

Guidance literature:

5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione; isobutyraldehyde; With piperidine; In dichloromethane; at 20 ℃; for 0.166667h;

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.166667h;

phlorisobutyrophenone; In dichloromethane; for 24h; Reflux;

DOI:10.1002/anie.200903906

upstream raw materials:

phlorisobutyrophenone

5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione

isobutyraldehyde

2,2,4,4-tetramethyl-6-(2-methylpropylidene)-cyclohexane-1,3,5-trione