trans-2-methylcyclohexanecarboxylic acid

Base Information

• Chemical Name: trans-2-methylcyclohexanecarboxylic acid
• CAS No.: 15177-62-5
• Molecular Formula: C8H14 O2
• Molecular Weight: 142.198
• Mol file: 15177-62-5.mol

Synonyms:trans-2-Methylcyclohexanecarboxylicacid

Chemical Property of trans-2-methylcyclohexanecarboxylic acid

Chemical Property:

• Melting Point: 170-172 °C
• Boiling Point: 242.2°Cat760mmHg
• PKA: 5.43±0.28(Predicted)
• Flash Point: 110.7°C
• PSA: 37.30000
• Density: 1.025g/cm³
• LogP: 1.89730

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-2-methylcyclohexanecarboxylic acid

There total 45 articles about trans-2-methylcyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1-methylcyclohex-1-ene (591-49-1) + carbon dioxide (124-38-9,18923-20-1) → trans-2-methylcyclohexanecarboxylic acid (15177-62-5)

Guidance literature:

1-methylcyclohex-1-ene; With 9-borabicyclo[3.3.1]nonane dimer; In 2-methyltetrahydrofuran; at 70 ℃; for 24h; Sealed tube;

carbon dioxide; With copper(l) iodide; cesium fluoride; sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In 2-methyltetrahydrofuran; at 120 ℃; for 24h; regioselective reaction; Sealed tube;

DOI:10.1002/cssc.201903224

Reference yield:

carbon monoxide (201230-82-2) + methyl cyclohexane (82166-21-0) → Cyclohexylacetic acid (5292-21-7) + (+/-)-trans-3-methyl-cyclohexanecarboxylic acid (13293-59-9,73873-48-0,73873-49-1,77954-16-6,77954-17-7) + (+/-)-cis-3-methyl-cyclohexanecarboxylic acid (13293-59-9,73873-48-0,73873-49-1,77954-16-6,77954-17-7) + trans-2-methylcyclohexanecarboxylic acid (15177-62-5)

Guidance literature:

With dipotassium peroxodisulfate; trifluoroacetic acid; palladium diacetate; at 80 ℃; Further byproducts given;

DOI:10.1246/cl.1991.1433

Reference yield:

carbon monoxide (201230-82-2) + methyl cyclohexane (82166-21-0) → trans-4-methylcyclohexanecarboxylic acid (934-67-8,4331-54-8,13064-83-0) + (+/-)-trans-3-methyl-cyclohexanecarboxylic acid (13293-59-9,73873-48-0,73873-49-1,77954-16-6,77954-17-7) + (+/-)-cis-3-methyl-cyclohexanecarboxylic acid (13293-59-9,73873-48-0,73873-49-1,77954-16-6,77954-17-7) + trans-2-methylcyclohexanecarboxylic acid (15177-62-5)

Guidance literature:

With dipotassium peroxodisulfate; trifluoroacetic acid; palladium diacetate; at 80 ℃; Further byproducts given;

DOI:10.1246/cl.1991.1433

upstream raw materials:

ortho-methylbenzoic acid

2-benzofuran-1(3H)-one

1-chloro-2-methyl-cyclohexane

naphthalene-2-sulfonate

Downstream raw materials:

(+/-)-trans-2-methyl-cyclohexanecarboxylic acid amide

(+/-)-(trans-2-Methyl-cyclohexyl)-methanol

trans-2-methyl-1-(ethoxycarbonyl)cyclohexane

trans-1-carbomethoxy-2-methylcyclohexane

Refernces

• 1、 Juhl, Martin,Laursen, Simon L. R.,Huang, Yuxing,Nielsen, Dennis U.,Daasbjerg, Kim,Skrydstrup, Troels. "Copper-catalyzed carboxylation of hydroborated disubstituted alkenes and terminal alkynes with cesium fluoride". . p. 1392 - 1396. Retrieved 2017/05/24.
• 2、 Satoh, Ko-ichi,Watanabe, Jun,Takaki, Ken,Fujiwara, Yuzo. "Pd-Catalyzed Regio- and Stereo-selective Carboxylation of Cycloalkanes with CO". . p. 1433 - 1436. Retrieved 2007/10/02.